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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 24 - 35 (12page)
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Background and Objectives: Ancillary tests such as BRAFV600E mutation or immunohistochemical (IHC) assays have been utilized as complements to morphological criteria in diagnosing subsets of papillary thyroid carcinoma (PTC). Utilizing results from analysis by The Cancer Genome Atlas (TCGA), we evaluated the diagnostic value and feasibility of these ancillary tests in diagnosing follicular variant PTC (FVPTC). Materials and Methods: Clinical data and tissue samples were analyzed from 370 PTC patients, who had undergone thyroidectomy between December 2003 and July 2014. PTC was limited to conventional PTC (CVPTC), tall cell variant PTC (TCPTC), and FVPTC. Using multivariate analyses, FVPTC cases were compared to CVPTC and TCPTC cases. Surgical specimens were pyrosequenced for BRAFV600E mutation or stained for IHC markers such as CD56, galectin-3, cytokeratin 19 (CK19), or CD31. For the validation, a comprehensive analysis was performed for BRAFV600E mutation and quantitative mRNA expressional difference in TCGA. Results: Demographic differences were not observed between 159 CVPTC, 103 TCPTC, and 108 FVPTC cases. BRAFV600E mutation predominated in CVPTC＋TCPTC group, but not in FVPTC group (78.4% vs. 18.7%, p＜0.001), as suggested by TCGA (57.4% vs. 12.1%, p＜0.0001). IHC markers significantly distinguished FVPTC cases from CVPTC＋TCPTC cases. CD56 exhibited more intense staining in FVPTC cases (21.1% vs. 72.0%, p＜0.001). Galectin-3 and CK19 yielded limited values. CD31 correlated with lymphovascular invasion (r=0.847, p＜0.001). In analysis of TCGA, mRNA differential expression of these genes revealed their corresponding upregulation or downregulation. Conclusion: BRAFV600E mutation or TCGA-validated IHC assay could be recommended as ancillary tests for classifying PTC.
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참고문헌 (24)
참고문헌 신청
Adeniran AJ / 2006 / Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinoma
Ahn HS / 2014 / Korea's thyroid-cancer "epidemic"--screening and overdiagnosis / N Engl J Med 371 (19) : 1765 ~ 1767
Alshenawy HA / 2014 / Utility of immunohistochemical markers in diagnosis of follicular cell derived thyroid lesions / Pathol Oncol Res 20 (4) : 819 ~ 828
Barut F / 2010 / Universal markers of thyroid malignancies:galectin-3, HBME-1, and cytokeratin-19 / Endocr Pathol 21 (2) : 80 ~ 89
Capper D / 2011 / Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody / Acta Neuropathol 122 (1) : 11 ~ 19
Ahn HS / 2014 / Korea's thyroid-cancer "epidemic"--screening and overdiagnosis / N Engl J Med 371 (19) : 1765 ~ 1767
Alshenawy HA / 2014 / Utility of immunohistochemical markers in diagnosis of follicular cell derived thyroid lesions / Pathol Oncol Res 20 (4) : 819 ~ 828
Barut F / 2010 / Universal markers of thyroid malignancies:galectin-3, HBME-1, and cytokeratin-19 / Endocr Pathol 21 (2) : 80 ~ 89
Capper D / 2011 / Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody / Acta Neuropathol 122 (1) : 11 ~ 19
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