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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 53 - 57 (5page)
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Purpose: Coexistence of different classes of β-lactamases in a single bacterial isolate may pose diagnostic and therapeutic challenges. We investigated a spread of Klebsiella pneumoniae isolates co-producing an AmpC β-lactamase and an extended- spectrum β-lactamase (ESBL) in a university hospital. Materials and Methods: Over a three-month period, a total of 11 K. pneumoniae isolates, which exhibited resistance to cefotaxime, aztreonam, and cefoxitin, were isolated. These isolates showed positive to ESBLs by double disk tests. Minimal inhibitory concentrations (MICs) were determined by broth microdilution testing. All isolates were examined by isoelectric focusing, PCR and sequence analysis to identify blaSHV and blaDHA, and molecular typing by pulsed-field gel electrophoresis (PFGE). Results: All 11 isolates were highly resistant (MIC, ≥128 μg/ml) to ceftazidime, aztreonam, and cefoxitin, while they were susceptible (MIC, ≤2 μg/ml) to imipenem. The blaSHV-12 and blaDHA-1 genes were detected by PCR and sequence analysis. PFGE revealed a similar pattern in 10 of the 11 strains tested. Conclusion: This is the first outbreak report of K. pneumoniae in Korea which co-produced SHV-12 and DHA-1 β-lactamase, and we suggest a clonal spread of multidrug-resistant K. pneumoniae at a hospital.
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참고문헌 (20)
참고문헌 신청
Black JA / 2005 / AmpC disk test for detection of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking chromosomal AmpC β- lactamases / J Clin Microbiol 43 : 3
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol R
Brun-Buisson C / 1987 / Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae / Lancet 2 : 3
Clinical and Laboratory Standards Institute / 2006 / Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard. M7-A7. 7th ed / Clinic
Clinical and Laboratory Standards Institute / 2007 / Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement / Clinical and Laboratory Standa
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol R
Brun-Buisson C / 1987 / Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae / Lancet 2 : 3
Clinical and Laboratory Standards Institute / 2006 / Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard. M7-A7. 7th ed / Clinic
Clinical and Laboratory Standards Institute / 2007 / Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement / Clinical and Laboratory Standa
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