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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 367 - 370 (4page)
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초록· 키워드
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The prevalence of multidrug-resistant gram-negative bacteria has continuously increased over the past few years; bacterial strains producing AmpC β-lactamases and/or extendedspectrum β-lactamases (ESBLs) are of particular concern. We combined high-resolution whole genome sequencing and phenotypic data to elucidate the mechanisms of resistance to cephamycin and β-lactamase in Korean Klebsiella pneumoniae strains, in which no AmpC-encoding genes were detected by PCR. We identified several genes that alone or in combination can potentially explain the resistance phenotype. We showed that different mechanisms could explain the resistance phenotype, emphasizing the limitations of the PCR and the importance of distinguishing closely-related gene variants.
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참고문헌 (13)
참고문헌 신청
Jacoby GA / 2009 / AmpC ${\beta}$ -Lactamases / Clin Microbiol Rev 22:161~182
Gupta G / 2014 / Detection of AmpC ${\beta}$ lactamases in gramnegative bacteria / J Lab Physicians 6:1~6
Coudron PE / 2005 / Inhibitor-based methods for detection of plasmid-mediated AmpC ${\beta}$ -lactamases in Klebsiella spp., Escherichia coli, and Proteus mirabilis / J Clin Microbiol 43:4163~4167
Perez-Perez FJ / 2002 / Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR / J Clin Microbiol 40:2153~2162
Tsai YK / 2011 / Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence / Antimicrob Agents Chemother 55:1485~1493
Gupta G / 2014 / Detection of AmpC
Coudron PE / 2005 / Inhibitor-based methods for detection of plasmid-mediated AmpC
Perez-Perez FJ / 2002 / Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR / J Clin Microbiol 40:2153~2162
Tsai YK / 2011 / Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence / Antimicrob Agents Chemother 55:1485~1493
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