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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 389 - 396 (8page)
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초록· 키워드
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Resent studies have reported increased isolation of extended-spectrum β-lactamase (ESBL) producing strains at sevearal hospital in Korea. We studied to investigate the isolation rates of ESBL strains from clinical isolates of Klebsiella pneumoniae and to characterize differences in types using analyses of genotyping and antibiotic susceptibility test. Antibiotic susceptibility test with confirmation of ESBL by double disk synergy test was performed on the 54 ESBL strains of Klebsoella pneumoniae from a hospital in Busan. Transfer of resistant gene in ESBL strains resistant to 3rd generated antibiotics was confirmed by transconjugation test using E. coli RG176<sup>nalⓡ</sup>. blaTEM, blaSHV, blaCTX-M genes were detected by PCR. ESBL producing strains had 100% of resistant rate to ampicillin, azteronam, cefazolin, cefepime and ceftriaxone (β-lactam antibiotics). Forty strains of bla TEM (74%), 41 strains of bla SHV (76%), 23 strains of bla CTX-M (43%) were found, respectively, The strains had one or more genes. They had high resistant rates to β-lactam antibiotics including cephalosporin. The resistant rates of strains with multiple resistant genes were higher than those of strains with single resistant gene.
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재료 및 방법
결과
고찰
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - GM,Arlet / 1994 / Molecular epidemiology of Klebsiella pneumoniae strains that produce SHV-4 lactamase and which were isolated in 14 French hospitals / J Clin Microbiol. 32 : 2553 ~ 2558
[학술지(정기간행물)] - HJ,Bae / 1997 / Characterization and type of extended-spectrum β-lactamase producing Klebsiella pneumoniae isolated in Korea / Infection 29 : 93 ~ 103
[학술지(정기간행물)] - R,Bonnet / 2004 / Growing group of extended-spectrum-lactamases: the CTX-M enzymes / Antimicrob Agents Chemother 48 : 1 ~ 14
[학술지(정기간행물)] - C,Branger / 1998 / Longterm investigation of the clonal dissemination of Klebsiella pneumoniae isolates producing extended-spectrum β-lactamases in a university hospital / J Med Microbiol. 47 : 201 ~ 209
[학술지(정기간행물)] - Bush K / 1989 / Characterization of β-lactamases / Antimicrob Agents Chemother. 33 : 259 ~
[학술지(정기간행물)] - HJ,Bae / 1997 / Characterization and type of extended-spectrum β-lactamase producing Klebsiella pneumoniae isolated in Korea / Infection 29 : 93 ~ 103
[학술지(정기간행물)] - R,Bonnet / 2004 / Growing group of extended-spectrum-lactamases: the CTX-M enzymes / Antimicrob Agents Chemother 48 : 1 ~ 14
[학술지(정기간행물)] - C,Branger / 1998 / Longterm investigation of the clonal dissemination of Klebsiella pneumoniae isolates producing extended-spectrum β-lactamases in a university hospital / J Med Microbiol. 47 : 201 ~ 209
[학술지(정기간행물)] - Bush K / 1989 / Characterization of β-lactamases / Antimicrob Agents Chemother. 33 : 259 ~
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