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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 89 - 98 (10page)
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초록· 키워드
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β-lactamases are the most widespread cause of bacterial resistance to β-lactam antibiotics, such as the penicillins and cephalosporins, and the mechanisms of these enzymes are intensely studied. The first β-lactamase was identified in an isolate of Escherichia coli in 1940. Many of the gram-negative bacteria possess a naturally occurring, chromosomally mediated β-lactamase, which probably assists the bacteria in finding a niche when faced with competition from other bacteria that naturally produce β-lactams. β-lactamases are classified into two major types on the basis of the main component of the active site: serineβ-lactamases and metallo-β-lactamases. Serineβ-lactamases are further classified into three classes: class A, C, and D; i.e.,metalloβ-lactamase is classified into class B. As is well known, the catalytic mechanism of serineβ-lactamases involves acylation and deacylation. In this paper, we have investigated the mechanisms of class A β-lactamase, most of which have extended spectrum β-lactamases belonging to that of the other classes B,C, and D β-lactamase.
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참고문헌 (24)
참고문헌 신청
Ambler RP / 1980 / The structure of β-lactamases / Philos Trans R Soc Lond B Biol Sci 289 (1036) : 321 ~ 331
Bonnet R / 2004 / Growing group of extended-spectrumβ-lactamases: the CTX-M enzymes / AntimicrobAgents Chemother 48 (1) : 1 ~ 14
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol
Bush K / 1995 / A functional classification scheme for β-lactamases and its correlation with molecular structure / Antimicrob Agents Chemother 39 (6) : 1211 ~ 1233
Canton R / 2006 / The CTX-M β-lactamase pandemic / Curr Opin Microbiol 9 (5) : 466 ~ 475
Bonnet R / 2004 / Growing group of extended-spectrumβ-lactamases: the CTX-M enzymes / AntimicrobAgents Chemother 48 (1) : 1 ~ 14
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol
Bush K / 1995 / A functional classification scheme for β-lactamases and its correlation with molecular structure / Antimicrob Agents Chemother 39 (6) : 1211 ~ 1233
Canton R / 2006 / The CTX-M β-lactamase pandemic / Curr Opin Microbiol 9 (5) : 466 ~ 475
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