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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 280 - 284 (5page)
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초록· 키워드
오류제보하기
Background: Among the inducible AmpC β-lactamase-producing members of the family Enterobacteriaceae such as Enterobacter spp., Citrobacter spp., Serratia spp.,and Morganella morganii (ECSM), the prevalence of ESBL-producing isolates are increasing. However, there have been only a limited number of studies that have investigated the prevalence for ESBL-production in blood isolates of these organisms.
Materials and Methods: We performed a prospective observational study to evaluate the prevalence for ESBL production among ECSM blood isolates. All consecutive blood isolates in the Samsung Medical Center were included from Oct 2006 to Mar 2008. Antimicrobial susceptibility test was performed by broth microdilution method. ESBLs were confirmed by double-disk synergy test and ESBL phenotypes were determined by PCR.
Results: The 124 isolates (94 Enterobacter spp., 18 Citrobacter spp., 8 Serratia spp.
and 4 Morganella spp.) were investigated. Among 124 ESCM isolates, 30 isolates (24.2%) showed ESBL-producing activity. Derepressed or partially derepressed AmpC mutants and derepressed AmpC mutants with ESBL production accounted for 36.3% (45/124) and 16.9% (21/124), respectively. Of ESBL producers, the most prevalent ESBL was SHV-12 (5/24, 20.8%).
Conclusions: The prevalence of ESBL-producing isolates is high in Enterobacter spp.,Serratia marcescens and Citrobacter spp. clinical isolates. It suggested that routine screening test for ESBLs among Enterobacteriacae blood isolates with inducible AmpC β-lactamase should be needed.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Bell JM / 2003 / Prevalence of extended-spectrum beta-lactamaseproducing Enterobacter cloacae in the Asia-Pacific region: results from the SENTRY Antimicrobial Surveillance
Choi SH / 2007 / Prevalence, microbiology, and clinical characteristics of extended-spectrum beta-lactamase-producing Enterobacter spp., Serratia marcescens , Citrobacter fre
Chow JW / 1999 / Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary / Int J Antimicrob Agents 11 : 7 ~ 12
Jacoby GA / 1996 / Detection of extended-spectrum betalactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli / J Clin Microbiol 34 : 908 ~ 911
Kim J / 2005 / Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii , Enterobacter spp., and
Choi SH / 2007 / Prevalence, microbiology, and clinical characteristics of extended-spectrum beta-lactamase-producing Enterobacter spp., Serratia marcescens , Citrobacter fre
Chow JW / 1999 / Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary / Int J Antimicrob Agents 11 : 7 ~ 12
Jacoby GA / 1996 / Detection of extended-spectrum betalactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli / J Clin Microbiol 34 : 908 ~ 911
Kim J / 2005 / Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii , Enterobacter spp., and
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