지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 102 - 107 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Molecular magnetic resonance (MR) imaging technique using the superparamagnetic iron oxide
nanocrystals (SPIO) are developed for the monitoring the stem cells noninvasively. This study was performed
to monitor the transplanted SPIO labelled human mesenchymal stem cells (hMSCs) with the molecular MR imaging
and histologically in the rat bladder.
Materials and Methods: SPIO (Feridex; AMI, Cambridge, MA, USA) were labelled to hMSCs using
GenePORTER. The labeling viability, efficiency of the SPIO labelled hMSCs were examined with tripan blue,
prussian blue staining. SPIO labelled hMSCs are transplanted to the bladder in rats and MR images of them
were examined using 1.5 T MR. Histologic examination of the SPIO labelled hMSCs transplanted bladder was
performed with H&E and prussian blue staining.
Results: The viability, efficiency of the SPIO labelled hMSCs were good. MR signal intensity at the areas
of the SPIO labelled hMSCs in the bladder decreased after transplantation of 1x106 SPIO labelled hMSCs and
were confined locally. Intracellular SPIO were confirmed in the hMSCs transplanted bladder up to 5 weeks.
Conclusion: The SPIO labelled hMSCs in the bladder can be monitored using the molecular MR imaging
and SPIO labelled hMSCs were found in the transplanted bladder. (J. Korean Continence Society 005;9:102-
107)
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
/ 1999 / RES-specificimaging of the liver and spleen with iron oxide particlesdesigned for blood pool MR-angiography 10 : 461 ~ 467
/ 2000 / Tat peptide-derivatized magnetic nanoparticles allowin vivo tracking and recovery of progenitor cells 18 : 410 ~ 414
/ 2001 / Magnetic labeling of activated microglia in experimentalgliomas 3 : 489 ~ 499
/ 2003 / In vivo magnetic resonanceimage of mesenchymal stem cells in myocardial infarction 107 : 2290 ~ 2293
/ 2003 / Science to practice:how can superparamagneticiron oxides be used to monitor disease and treatment? 229 : 615 ~ 616
/ 2000 / Tat peptide-derivatized magnetic nanoparticles allowin vivo tracking and recovery of progenitor cells 18 : 410 ~ 414
/ 2001 / Magnetic labeling of activated microglia in experimentalgliomas 3 : 489 ~ 499
/ 2003 / In vivo magnetic resonanceimage of mesenchymal stem cells in myocardial infarction 107 : 2290 ~ 2293
/ 2003 / Science to practice:how can superparamagneticiron oxides be used to monitor disease and treatment? 229 : 615 ~ 616
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