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논문 기본 정보

자료유형
학술저널
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저널정보
대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제17권 제3호
발행연도
2013.1
수록면
181 - 191 (11page)

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Purpose : To evaluate the usefulness of in vivo magnetic resonance (MR) imaging for tracking intravenously injected superparamagnetic iron oxide (SPIO)-labeled human umbilical vein endothelial cells (HUVECs) in an acute renal failure (ARF) rat model. Materials and Methods: HUVECs were labeled with SPIO and poly-L-lysine (PLL) complex. Relaxation rates at 1.5-T MR,cell viability, and labeling stability were assessed. HUVECs were injected into the tail vein of ARF rats (labeled cells in 10rats, unlabeled cells in 2 rats). Follow-up serial T2*-weighted gradient-echo MR imaging was performed at 1, 3, 5 and 7days after injection, and the MR findings were compared with histologic findings. Results: There was an average of 98.4±2.4% Prussian blue stain-positive cells after labeling with SPIOPLL complex. Relaxation rates (R2*) of all cultured HUVECs at day 3 and 5 were not markedly decreased compared with that at day 1. The stability of SPIO in HUVECs was maintained during the proliferation of HUVECs in culture media. In the presence of left unilateral renal artery ischemia, T2*-weighted MR imaging performed 1 day after the intravenous injection of labeled HUVECs revealed a significant signal intensity (SI) loss exclusively in the left renal outer medulla regions, but not in the right kidney. The MR imaging findings at days 3, 5 and 7 after intravenous injection of HUVECs showed a SI loss in the outer medulla regions of the ischemically injured kidney, but the SI progressively recovered with time and the right kidney did not have a significant change in SI in the same period. Upon histologic analysis, the SI loss on MR images was correspondent to the presence of Prussian blue stained cells, primarily in the renal outer medulla. Conclusion: MR imaging appears to be useful for in vivo monitoring of intravenously injected SPIO-labeled HUVECs in an ischemically injured rat kidney.
#Magnetic resonance imaging #MRI) #Superparamagnetic iron oxide #SPIO)Human umbilical vein endothelial cells #HUVECs) #Cell tracking

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참고문헌 (23)

참고문헌 신청
Arbab AS / 2003 / Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellul google schola Arbab AS / 2004 / Comparison of transfection agents in forming complexes with ferumoxides, cell labeling efficiency, and cellular viability / Mol Imaging 3 : 24 ~ 32 google schola Artemov D / 2003 / Molecular magnetic resonance imaging with targeted contrast agents / J Cell Biochem 90 : 518 ~ 524 google schola Basile DP / 2001 / Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function / Am J Physiol Renal Physiol 281 : 887 ~ 89 google schola Bos C / 2004 / In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver / Radiology 233 : 781 ~ 789 google schola

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