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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 189 - 196 (8page)
- DOI
- 10.14815/kjdm.2011.09.38.3.189
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We prepared ultra violet (UV) light irradiated TiO<SUB>2</SUB> nanotube array on eletropolished titanium surface and estimated the effect of the UV treatment of TiO<SUB>2</SUB> nanotubular structure on the adhesion, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) in terms of different diameters (30 - 100 nm) of TiO<SUB>2</SUB> nanotubes. Fluorescein diacetate assay resulted that the initial adhesion of hMSCs did not show any sign ifican t difference between all TiO<SUB>2</SUB> nanotube diameter (p>0.05). However, the proliferation of hMSCs cultured on electropolished Ti surface were higher than those cultured on 50, 70, and 100 nm TiO<SUB>2</SUB> nanotubes (p<0.05) From the results of RT-PCR assay, the values of i ntegrin β1, osteocalcin, osteoponting, and alkaline phosphatase did not show any significant difference between all experimental groups after 1week of incubation period. However, the value of alkaline phosphatase showed the tendency of increasing with proportional to the diameter of TiO<SUB>2</SUB> nanotubes. Therefore, we can expect the UV treatment of TiO<SUB>2</SUB> nanotube did not affect he adhesion, proliferation, and osteogenic differentiation of hMSCs compared to non UV treated TiO<SUB>2</SUB> nanotube. Also, the enlargement of nanotube diameter is supposed to promote osteogenic differentiation of hMSCs from all results of this study.
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ABSTRACT
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참고문헌
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Boudreau NJ / 1999 / Extracellular matrix and integrin signalling: the shape of things to come / Biochem J 3 : 481 ~ 488
2. [학술지(정기간행물)] - Caplan AI / 2005 / Review: mesenchymal stem cells : cell-based reconstructive therapy in orthopedics / Tissue Eng 11 : 1198 ~ 1211
3. [학술지(정기간행물)] - Dulgar-Tulloch AJ / 2011 / Differentiation of human mesenchymal stem cells on nano- and micro-grain size titania / Materials Science and Engineering 31 : 357 ~ 362
4. [학술지(정기간행물)] - Friedenstein AJ / 1976 / Precursor cells of mechanocytes / Int Rev Cytol 47 : 327 ~ 359
5. [학술지(정기간행물)] - Hallab NJ / 1995 / Cell adhesion to biomaterials: correlations between surface c harge, s urface roughn ess, a dsorbed protein, and cell morphology / J Long Term Eff Med Implants 5 : 209 ~ 231
2. [학술지(정기간행물)] - Caplan AI / 2005 / Review: mesenchymal stem cells : cell-based reconstructive therapy in orthopedics / Tissue Eng 11 : 1198 ~ 1211
3. [학술지(정기간행물)] - Dulgar-Tulloch AJ / 2011 / Differentiation of human mesenchymal stem cells on nano- and micro-grain size titania / Materials Science and Engineering 31 : 357 ~ 362
4. [학술지(정기간행물)] - Friedenstein AJ / 1976 / Precursor cells of mechanocytes / Int Rev Cytol 47 : 327 ~ 359
5. [학술지(정기간행물)] - Hallab NJ / 1995 / Cell adhesion to biomaterials: correlations between surface c harge, s urface roughn ess, a dsorbed protein, and cell morphology / J Long Term Eff Med Implants 5 : 209 ~ 231
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