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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 520 - 526 (7page)
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초록· 키워드
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Objective: To define the migration and differentiation of adult human mesenchymal stem cells (hMSCs) derived from bone marrow, and their effect on neurobehavioral and cognitive improvements, after traumatic brain injury (TBI) in rats.
Method: Two days after TBI, 1×106 hMSCs were injected into the corpus callosum of fifteen rats, on the contralateral side of TBI. Eleven rats received sham-operation as a control group. Neurobehavioral and Barnes maze tests, and magnetic resonance spectroscopy (MRS) were performed on days 1 and 28 after TBI. Immunohistochemical staining was performed to evaluate distribution and differentiation of hMSCs on day 56.
Results: After 28 days, scores on the neurobehavioral test, Barnes maze test, and magnetic resonance spectroscopy (MRS) were higher than on day 1 in both the stem-cell and control groups, but there were no between-group differences. On day 56, injected hMSCs stained positively with MAB- 1281 were distributed in ipsilateral corpus callosum, lesion boundary zone, parietal cortex, and thalamic area around the lateral ventricle.
Conclusion: hMSCs injected to the contralateral side of TBI survive and migrate to various areas of the ipsilateral hemisphere. We observed no neurobehavioral or cognitive improvements in test animals, indicating the need to adjust experimental methodologies including the development of appropriate tests to evaluate neurobehavioral and cognitive functions of rats.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Adams JH / 2000 / The neuropathology of the vegetative state after an acute brain insult / Brain 123 : 1327 ~ 1338
Barinaga M / 2000 / Fetal neuron grafts pave the way for stem cell therapies / Science 287 : 1421 ~ 1422
Barnes CA / 1979 / Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat / J Comp Physiol Psychol 93 : 74 ~ 104
Barry FP / 2003 / Biology and clinical applications of mesenchymal stem cells / Birth Defects Res C Embryo Today 69 : 250 ~ 256
Cecil KM / 1998 / High-field proton magnetic resonance spectroscopy of a swine model for axonal injury / J Neurochem 70 : 2038 ~ 2044
Barinaga M / 2000 / Fetal neuron grafts pave the way for stem cell therapies / Science 287 : 1421 ~ 1422
Barnes CA / 1979 / Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat / J Comp Physiol Psychol 93 : 74 ~ 104
Barry FP / 2003 / Biology and clinical applications of mesenchymal stem cells / Birth Defects Res C Embryo Today 69 : 250 ~ 256
Cecil KM / 1998 / High-field proton magnetic resonance spectroscopy of a swine model for axonal injury / J Neurochem 70 : 2038 ~ 2044
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