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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 23 - 29 (7page)
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초록· 키워드
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Background: Neuropathic pain (NP) is considered a clinically incurable condition despite various treatment options due to its diverse causes and complicated disease mechanisms. Since the early 2000s, multipotent human mesenchymal stem cells (hMSCs) have been used in the treatment of NP in animal models. However, the effects of hMSC injections have not been studied in chronic post-ischemia pain (CPIP) mice models. Here, we investigated whether intrathecal (IT) and intrapaw (IP) injections of hMSCs can reduce mechanical allodynia in CPIP model mice. Methods: Seventeen CPIP C57/BL6 mice were selected and randomized into four groups: IT sham (n = 4), IT stem (n = 5), IP sham (n = 4), and IP stem (n = 4). Mice in the IT sham and IT stem groups received an injection of 5 μL saline and 2 × 104 hMSCs, respectively, while mice in the IP sham and IP stem groups received an injection of 5 μL saline and 2 × 105 hMSCs, respectively. Mechanical allodynia was assessed using von Frey filaments from pre-injection to 30 days post-injection. Glial fibrillary acidic protein (GFAP) expression in the spinal cord and dorsal root ganglia were also evaluated. Results: IT and IP injections of hMSCs improved mechanical allodynia. GFAP expression was decreased on day 25 post-injection compared with the sham group. Injections of hMSCs improved allodynia and GFAP expression was decreased compared with the sham group. Conclusions: These results suggested that hMSCs may be also another treatment modality in NP model by ischemia-reperfusion.
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참고문헌 (43)
참고문헌 신청
Hatch MN / 2018 / Neuropathic pain and SCI : identification and treatment strategies in the 21st century / J Neurol Sci 384:75~83
Siniscalco D / 2007 / Molecular approaches for neuropathic pain treatment / Curr Med Chem 14:1783~1787
Cao Q / 2002 / Stem cell repair of central nervous system injury / J Neurosci Res 68:501~510
Lindvall O / 2005 / Stem cell therapy for human brain disorders / Kidney Int 68:1937~1939
Lindvall O / 2006 / Stem cells for the treatment of neurological disorders / Nature 441:1094~1096
Siniscalco D / 2007 / Molecular approaches for neuropathic pain treatment / Curr Med Chem 14:1783~1787
Cao Q / 2002 / Stem cell repair of central nervous system injury / J Neurosci Res 68:501~510
Lindvall O / 2005 / Stem cell therapy for human brain disorders / Kidney Int 68:1937~1939
Lindvall O / 2006 / Stem cells for the treatment of neurological disorders / Nature 441:1094~1096
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