지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 196 - 203 (8page)
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초록· 키워드
오류제보하기
Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell viability and osteogenic differentiation. We also investigated regenerative effect of hMSCs with the scaffold in a calvarial bone defect model. Formation of new bone was evaluated by micro-CT, histology and expression of osteogenic markers. The results clearly showed interesting evidence indicating that hMSCs with scaffold increased the formation of new bone and expression of osteogenic markers, compared to the empty and scaffold only groups. Overall, our results suggest that hMSCs with scaffold are suitable for stimulation of intense bone regeneration in critical-sized bone defects.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - Koob S / 2011 / Bone formation and neovascularization mediated by mesenchymal stem cells and endothelial cells in critical-sized calvarial defects / Tissue Eng Part A 17 : 311 ~ 321
2. [학술지(정기간행물)] - Levi B / 2010 / Human adipose derived stromal cells heal critical size mouse calvarial defects / PLoS One 5 (6) : 11177 ~
3. [학술지(정기간행물)] - Zong C / 2010 / Reconstruction of rat calvarial defects with human mesenchymal stem cells and osteoblast-like cells in poly-lactic-co-glycolic acid scaffolds / Eur Cell Mater 20 : 109 ~ 120
4. [학술지(정기간행물)] - Amorosa LF / 2013 / Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study / Int J Nanomedicine 8 : 1637 ~ 1643
5. [학술지(정기간행물)] - Xing Z / 2011 / Effect of endothelial cells on bone regeneration using poly(L-lactide-co- 1,5-dioxepan-2-one) scaffolds / J Biomed Mater Res 96 (2) : 349 ~ 357
2. [학술지(정기간행물)] - Levi B / 2010 / Human adipose derived stromal cells heal critical size mouse calvarial defects / PLoS One 5 (6) : 11177 ~
3. [학술지(정기간행물)] - Zong C / 2010 / Reconstruction of rat calvarial defects with human mesenchymal stem cells and osteoblast-like cells in poly-lactic-co-glycolic acid scaffolds / Eur Cell Mater 20 : 109 ~ 120
4. [학술지(정기간행물)] - Amorosa LF / 2013 / Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study / Int J Nanomedicine 8 : 1637 ~ 1643
5. [학술지(정기간행물)] - Xing Z / 2011 / Effect of endothelial cells on bone regeneration using poly(L-lactide-co- 1,5-dioxepan-2-one) scaffolds / J Biomed Mater Res 96 (2) : 349 ~ 357
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