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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 125 - 131 (7page)
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초록· 키워드
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The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced TMJ nociception. Experiments were carried out using male Sprague-Dawley rats. Intra-articular injection of 3% formalin was administered to evaluate hyperalgesia 3 days after CFA injection. Intra-articular injection of 3% formalin did not produce nociceptive behavior in normal rats. Although intra-articular injection of 3 doses of CFA produced TMJ inflammation, only 1:3 diluted CFA produced hyperalgesia when formalin was injected intra-articularly 3 days after CFA injection. Co-administration of IL-1 receptor inhibitor with formalin into the TMJ cavity 3 days after CFA injection was performed. Co-administration of IL-1 receptor inhibitor significantly inhibited formalin-induced hyperalgesia in rats with CFA-induced TMJ inflammation. These results suggested that intra-articular injection of formalin produced hyperalgesia under chronic TMJ inflammation. Moreover, IL-1β plays an important role in TMJ hyperalgesia under chronic inflammation and blockade of IL-1β is a potential therapeutic target for inflammatory TMJ pain.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Roveroni RC / 2001 / Development of a behavioral model of TMJ pain in rats: the TMJ formalin test / Pain 94:185~191
Dong K. Ahn / 2005 / Central cyclooxygenase inhibitors reduced IL-1β-induced hyperalgesia in temporomandibular joint of freely moving rats / Pain 117(1):204~213
Won KA / 2012 / Participation of microglial p38 MAPK in formalininduced temporomandibular joint nociception in rats / J Orofac Pain 26:132~141
Cairns BE / 1998 / Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles / J Neurosci 18:8056~8064
Yu XM / 1995 / Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity / Pain 60:143~149
Dong K. Ahn / 2005 / Central cyclooxygenase inhibitors reduced IL-1β-induced hyperalgesia in temporomandibular joint of freely moving rats / Pain 117(1):204~213
Won KA / 2012 / Participation of microglial p38 MAPK in formalininduced temporomandibular joint nociception in rats / J Orofac Pain 26:132~141
Cairns BE / 1998 / Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles / J Neurosci 18:8056~8064
Yu XM / 1995 / Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity / Pain 60:143~149
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