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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 106 - 111 (6page)
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Glutaredoxin 1 (GLRX1) has been recognized as an important regulator of redox signaling. Although GLRX1 plays an essential role in cell survival as an antioxidant protein, the function of GLRX1 protein in inflammatory response is still under investigation. Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation. In LPS-exposed Raw 264.7 cells, PEP-1-GLRX1 inhibited cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), activation of mitogen activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-κB) expression levels. In a TPA-induced mouse-ear edema model, topically applied PEP-1-GLRX1 transduced into ear tissues and significantly ameliorated ear edema. Our data reveal that PEP-1-GLRX1 attenuates inflammation in vitro and in vivo, suggesting that PEP-1-GLRX1 may be a potential therapeutic protein for inflammatory diseases.
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참고문헌 (54)
참고문헌 신청
Medzhitov R / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Tsaryk R / 2013 / The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6A14V alloy / Biomaterials 34:8075~8085
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
Hiraiwa K / 2013 / Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants / Mediators Inflamm 2013:619523
Jin SE / 2016 / Anti-inflammatory effect and action mechanisms of traditional herbal formula Gamisoyo-san in RAW 264.7 macrophages / BMC Complement Altern Med 16:219
Tsaryk R / 2013 / The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6A14V alloy / Biomaterials 34:8075~8085
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
Hiraiwa K / 2013 / Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants / Mediators Inflamm 2013:619523
Jin SE / 2016 / Anti-inflammatory effect and action mechanisms of traditional herbal formula Gamisoyo-san in RAW 264.7 macrophages / BMC Complement Altern Med 16:219
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