A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica

Mahshid Mostafavi; Payam Khazaeli; Iraj Sharifi; Saeedeh Farajzadeh; Hamid Sharifi; Alireza Keyhani; Maryam Hakimi Parizi; Sina Kakooei

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자료유형: 학술저널

저자정보: Mahshid Mostafavi (Kerman University of Medical Sciences) Payam Khazaeli (Kerman University of Medical Sciences) Iraj Sharifi (Kerman University of Medical Sciences) Saeedeh Farajzadeh (Kerman University of Medical Sciences) Hamid Sharifi (Kerman University of Medical Sciences) Alireza Keyhani (Kerman University of Medical Sciences) Maryam Hakimi Parizi (Kerman University of Medical Sciences) Sina Kakooei (Kerman University of Medical Sciences)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.57 No.1

발행연도: 2019.2

수록면: 1 - 8 (8page)

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There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were characterized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory effects (P≤0.001) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleukin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased (P≤0.001). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and enhanced their lethal activity as evidenced by the in vitro experiments.

#Leishmania tropica #selenium #glucantime #niosomes #anti-leishmanial effect #cytokine

참고문헌 (42)

참고문헌 신청

Alvar J / 2012 / Leishmaniasis worldwide and global estimates of its incidence / PLoS One 7:e35671

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Karimi A / 2014 / Spatial and temporal distributions of phlebotomine sand flies(Diptera : Psychodidae), vectors of leishmaniasis, in Iran / Acta Trop 132:131~139

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Sharifi I / 2015 / A comprehensive review of cutaneous leishmaniasis in kerman province, southeastern irannarrative review article / Iran J Public Health 44:299~307

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