지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 301 - 309 (9page)
이용수
초록· 키워드
오류제보하기
Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water. Group III given silver as silver nitrate (AgNO₃) (20 mg/L). Group IV given vitamin E and AgNO₃. Group V given both AgNO₃ and selenium. Group VI given AgNO₃, vitamin E and Se. The animals were in the same exposure conditions for 3 months. According to the results which have been obtained; there was an increase in serum lactate dehydrogenase (LDH), lipase activities and cholesterol level, a decrease in serum total protein, calcium and alkaline phosphatase (ALP) activity in Agintoxicated rats. Moreover, the findings showed that Ag+ ions affected antioxidant defense system by decreasing superoxide dismutase (SOD) activity and increasing vitamin E concentration with a high level of malondialdehyde (MDA) in brain tissue. The histological examination also exhibited some nervous tissue alterations including hemorrhage and cytoplasm vacuolization. However, the co-administration of selenium and/or vitamin E ameliorated the biochemical parameters and restored the histological alterations. In conclusion, this study indicated that silver could cause harmful effects in animal body and these effects can be more toxic in high concentrations or prolonged time exposure to this metal. However, selenium and vitamin E act as powerful antioxidants which may exercise adverse effect against the toxicity of this metal.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (57)
참고문헌 신청
Powers, C. M / 2010 / Silver impairs neurodevelopment:studies in PC12 cells / Environ. Health Perspect 118:73~79
이연진 / 2012 / A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring / 한국독성학회지 28(3):139~141
노지연 / 2012 / Involvement of Caenohabditis elegans MAPK Signaling Pathways in Oxidative Stress Response Induced by Silver Nanoparticles Exposure / 한국독성학회지 28(1):19~24
권정택 / 2012 / Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles / 한국독성학회지 28(1):25~31
WHO / 1996 / Silver in drinking-water in Guidelines for drinking-water quality / World Health Organization :338~343
이연진 / 2012 / A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring / 한국독성학회지 28(3):139~141
노지연 / 2012 / Involvement of Caenohabditis elegans MAPK Signaling Pathways in Oxidative Stress Response Induced by Silver Nanoparticles Exposure / 한국독성학회지 28(1):19~24
권정택 / 2012 / Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles / 한국독성학회지 28(1):25~31
WHO / 1996 / Silver in drinking-water in Guidelines for drinking-water quality / World Health Organization :338~343
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UCI(KEPA) : I410-ECN-0101-2017-513-001339567