지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 363 - 369 (7page)
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초록· 키워드
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Background/Aims: Studies on the micronutrient status of Asian patients with inflammatory bowel disease (IBD) are scarce. We evaluated the prevalence of micronutrient deficiency and verified the risk factors for micronutrient deficiency in Korean patients with IBD. Methods: We measured the serum levels of 25-hydroxyvitamin D3 [25-(OH)D], zinc, and selenium to analyze the clinical risk factors for micronutrient levels below the reference values. In addition, we compared the 25-(OH)D levels of patients with IBD to those of age- and sex-matched healthy controls. Results: Among the 83 patients, 74 (89.2%) had suboptimal serum 25-(OH)D levels. The mean plasma 25-(OH)D level in patients with IBD was significantly reduced compared to that of the healthy controls (12.3±6.2 ng/mL vs 20.0±6.7 ng/mL; p<0.001).
The proportions of patients with lower serum zinc and selenium levels were 39.0% and 30.9%, respectively. Female sex (p=0.012) and Crohn’s disease (p=0.012) were associated with vitamin D deficiency. Patients younger than 40 years were at increased risk for zinc deficiency (p=0.045).
Female sex (p=0.015) and low serum albumin level (<3.3 g/dL) (p=0.047) were risk factors for selenium deficiency.
Conclusions: Many Korean patients with IBD have vitamin D, zinc, and selenium deficiencies, suggesting the necessity for monitoring levels of these micronutrients.
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참고문헌 (27)
참고문헌 신청
Barnett M / 2010 / Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease / Mutat Res 690 : 71 ~ 80
Barrett CW / 2013 / Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis / PLoS One 8 : e67845 ~
Dawson AM / 1972 / Nutritional disturbances in Crohn’s disease / Br J Surg 59 : 817 ~ 819
Filippi J / 2006 / Nutritional deficiencies in patients with Crohn’s disease in remission / Inflamm Bowel Dis 12 : 185 ~ 191
Fu YT / 2012 / Hypovitaminosis D in adults with inflammatory bowel disease: potential role of ethnicity / Dig Dis Sci 57 : 2144 ~ 2148
Barrett CW / 2013 / Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis / PLoS One 8 : e67845 ~
Dawson AM / 1972 / Nutritional disturbances in Crohn’s disease / Br J Surg 59 : 817 ~ 819
Filippi J / 2006 / Nutritional deficiencies in patients with Crohn’s disease in remission / Inflamm Bowel Dis 12 : 185 ~ 191
Fu YT / 2012 / Hypovitaminosis D in adults with inflammatory bowel disease: potential role of ethnicity / Dig Dis Sci 57 : 2144 ~ 2148
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