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Niosomes: a potential tool for novel drug delivery
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Type
Academic journal
Author
Rizwana Khan (Bundelkhand University India) Raghuveer Irchhaiya (Bundelkhand University India)
Journal
Korean Society of Pharmaceutical Science and Technology Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제3호 KCI Accredited Journals
Published
2016.6
Pages
195 - 204 (10page)

Usage

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Niosomes: a potential tool for novel drug delivery
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Abstract· Keywords

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Vesicular drug delivery system are novel means to improve the bioavailability of the encapsulated drug along with numerous advantages over conventional drug delivery systems. Liposomes were first in such type of delivery systems but it was not so successful due to their numerous drawbacks. Niosomes or non ionic surfactant vesicles are formed from self assembly of hydrated surfactant monomers. They are formulated by non ionic surfactants but various ionic amphiphiles like di cetyl phosphate, sodium deoxycholate and stearylamine etc. are also incorporated inorder to achieve a stable vesicular suspension by inducing negative or positive charge. The most striking feature of such delivery system is that it can be used to encapsulate both hydrophobic as well as hydrophilic drug. The emphasis of this type of vesicular drug delivery system is placed over the slow release of drug in a controlled manner, resulting into sustained activity, reduced toxicity, protection of active moiety, targeting, modification in distribution profile of drugs and enhancing the bioavailability of encapsulated drug. This article summarizes the merits of niosomal drug delivery system over conventional drug therapy, its structural components, factors affecting its formation, method of preparation, evaluation techniques, therapeutic applications and patents.
#Niosomes #Surfactant #Bioavailability #Cholesterol #Charge #Hydration medium

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References (57)

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A. Abd-Elbary / 2008 / Sucrose stearate-based proniosome-derived niosomes for the nebulisable delivery of cromolyn sodium / International Journal of Pharmaceutics 357(1-2):189~198 Crossref Alcantar N. / 2008 / Niosome hydro gel drug delivery / US patent number US2008/0050445 A1 google schola Alcantar N. / 2010 / Niosome hydrogel drug delivery / US patent number US2010/0068264 A1 google schola H.O. Ammar / 2011 / Proniosomes as a carrier system for transdermal delivery of tenoxicam / International Journal of Pharmaceutics 405(1-2):142~152 Crossref Arunothayanun P. / 2000 / The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles(niosomes)formed from a hexadecyl diglycerol ether / Int J Pharm 201:7~14 google schola

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