Artemisinin-loaded niosome and pegylated niosome: physicochemical characterization and effects on MCF-7 cell proliferation

Elnaz Asgharkhani; Anahita Fathi Azarbayjani; Shiva Irani; Mohsen Chiani; Zahra Saffari; Dariush Norouzian; Azim Akbarzadeh; Seyed Mohammad Atyabi

doi:10.1007/s40005-017-0331-y

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저자정보: Elnaz Asgharkhani (Islamic Azad University) Anahita Fathi Azarbayjani (Urmia University of Medical Sciences) Shiva Irani (Islamic Azad University) Mohsen Chiani (Pasteur Institute of Iran) Zahra Saffari (Pasteur Institute of Iran) Dariush Norouzian (Pasteur Institute of Iran) Azim Akbarzadeh (Pasteur Institute of Iran) Seyed Mohammad Atyabi (Pasteur Institute of Iran)

저널정보: 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제3호

발행연도: 2018.5

수록면: 251 - 256 (6page)

DOI: 10.1007/s40005-017-0331-y

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Artemisinin (ART)-loaded niosome and pegylated niosomes were prepared using two different techniques. Nanosized lipid vesicles were physically characterized for entrapment efficacy and stability. Particle sizes were determined and release kinetic of the optimized formulation was carried out by dialysis method. The efficacy of the developed formulation was tested on MCF7 cells and cytotoxicity was accomplished by MTT assay. Common observation was the effect of pegylation on the reduction of vesicle size due to its hydrophilic nature. Span 60 niosomes had slightly larger vesicle size than Span 20 niosomes. Over all the good stability was observed over 60 days. In vitro drug release studies indicate gradual release of niosome over 40 h. similar trend in drug release was observed for most formulation except for the multilammellar pegylated niosomes. Pegylation of niosomes causes increased stability and efficacy of ART. Cytotoxicity ( IC50) was evaluated at different time of incubation at 48 and 72 h for selected niosomal formulations. Pegylated ART niosomes show great advantages in term of interaction with MCF-7 cell membrane. Results suggest that pegylated niosomes may be an appropriate candidate for the clinical administration of ART.

#Artemisinin #Niosome #Pegylated niosome #MCF 7 cell line #MTT assay #Drug release

참고문헌 (20)

참고문헌 신청

Chen Y / 2009 / Study of artemisinin nanocapsules as anticancer drug delivery system / Nanomedicine 5:316~322

Efferth T / 2004 / Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines / Biochem Pharmacol 68:3~10

Fang J-Y / 2001 / Effect of liposomes and niosomes on skin permeation of Enoxacin / Int J Pharm 219:61~72

Fathi Azarbayjani A / 2010 / Surface tension and wettability in transdermal delivery: a study on the in-vitro permeation of haloperidol with cyclodextrin across human epidermis / J Pharm Pharmacol 62:770~778

Fathi Azarbayjani A / 2011 / Development and characterization of skin permeation retardants and enhancers: a comparative study of Levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles / Biopharm Drug Dispos 32:380~388

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이 논문의 저자 정보

Elnaz Asgharkhani

소속기관 Islamic Azad University

주요연구분야 의약학 > 약학

논문수 1 이용수 2

Anahita Fathi Azarbayjani

소속기관 Urmia University of Medical Sciences

주요연구분야 의약학 > 약학

논문수 1 이용수 2

Shiva Irani

소속기관 Islamic Azad University

주요연구분야 의약학 > 약학

논문수 1 이용수 2

Mohsen Chiani