지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 697 - 702 (6page)
이용수
초록· 키워드
오류제보하기
Acanthamoeba keratitis has been increasing in recent years. Main risk factors are contact lens wear and their cleaning solutions. Most contact lens wearers use multipurpose disinfecting solutions (MPDS) for cleansing and disinfecting microorganisms because of its convenience. We determined amoebicidal effects of MPDS made in Korea and their cytotoxicity on human corneal epithelium cells. Fifteen commercial MPDS (A to O) were tested for their amoebicidal effects on Acanthamoeba castellanii trophozoites and cysts by using a most probable number (MPN) technique. Among them, 7 kinds of MPDS showed little or no amoebicidal effects for 24 hr exposure. Solutions A, B, G, H, L, and O showed positive amoebicidal effects, and solutions M and N killed almost all trophozoites and cysts after 24 hr exposure. However, 50%-N solution showed 56% cytotoxicity on human corneal epithelial cells within 4 hr exposure, and 50%-O solution also showed 62% cytotoxicity on human cells within 4 hr exposure. Solution A did not show any cytotoxicity on human cells. These results revealed that most MPDS made in Korea were ineffective to kill Acanthamoeba. The solutions having amoebicidal activity also showed high levels of cytotoxicity on human corneal epithelial cells. New formulations for improved MPDS that are amoebicidal but safe for host cells are needed to prevent Acanthamoeba keratitis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Marciano-Cabral F / 2003 / Acanthamoeba spp. as agents of disease in humans / Clin Microbiol Rev 16 : 273 ~ 307
[학술지(정기간행물)] - Marciano-Cabral F / 2000 / The increasing importance of Acanthamoeba infections / J Eukaryot Microbiol 47 : 29 ~ 36
[학술지(정기간행물)] - Stevenson RW / 1998 / Has the introduction of multi-purpose solutions contributed to a reduced incidence of Acanthamoeba keratitis in contact lens wearers? A review / Cont Lens Anterior Eye 21 : 89 ~ 92
[학술지(정기간행물)] - Stehr-Green JK / 1989 / The epidemiology of Acanthamoeba keratitis in the United States / Am J Ophthalmol 107 : 331 ~ 336
[학술지(정기간행물)] - Seal DV / 1999 / Acanthamoeba keratitis in Scotland : risk factors for contact lens wearers / Cont Lens Anterior Eye 22 : 58 ~ 68
[학술지(정기간행물)] - Marciano-Cabral F / 2000 / The increasing importance of Acanthamoeba infections / J Eukaryot Microbiol 47 : 29 ~ 36
[학술지(정기간행물)] - Stevenson RW / 1998 / Has the introduction of multi-purpose solutions contributed to a reduced incidence of Acanthamoeba keratitis in contact lens wearers? A review / Cont Lens Anterior Eye 21 : 89 ~ 92
[학술지(정기간행물)] - Stehr-Green JK / 1989 / The epidemiology of Acanthamoeba keratitis in the United States / Am J Ophthalmol 107 : 331 ~ 336
[학술지(정기간행물)] - Seal DV / 1999 / Acanthamoeba keratitis in Scotland : risk factors for contact lens wearers / Cont Lens Anterior Eye 22 : 58 ~ 68
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UCI(KEPA) : I410-ECN-0101-2017-513-002126422