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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 109 - 114 (6page)
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초록· 키워드
오류제보하기
Protein arginine methyltransferase (PRMT) is an important epigenetic regulator in eukaryotic cells. During encystation, an essential process for Acanthamoeba survival, the expression of a lot of genes involved in the encystations process has to be regulated in order to be induced or inhibited. However, the regulation mechanism of these genes is yet unknown. In this study, the full-length 1,059 bp cDNA sequence of Acanthamoeba castellanii PRMT1 (AcPRMT1) was cloned for the first time. The AcPRMT1 protein comprised of 352 amino acids with a SAM-dependent methyltransferase PRMT-type domain. The expression level of AcPRMT1 was highly increased during encystation of A. castellanii. The EGFPAcPRMT1 fusion protein was distributed over the cytoplasm, but it was mainly localized in the nucleus of Acanthamoeba. Knock down of AcPRMT1 by synthetic siRNA with a complementary sequence failed to form mature cysts. These findings suggested that AcPRMT1 plays a critical role in the regulation of encystation of A. castellanii. The target gene of AcPRMT1 regulation and the detailed mechanisms need to be investigated by further studies.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - Marciano-Cabral F / 2003 / Acanthamoeba spp. as agents of disease in humans / Clin Microbiol Rev 16 : 273 ~ 307
[학술지(정기간행물)] - 문은경 / 2011 / Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii / The Korean Journal of Parasitology 49 (4) : 341 ~ 347
[학술지(정기간행물)] - Portela A / 2010 / Epigenetic modifications and human disease / Nat Biotechnol 28 : 1057 ~ 1068
[학술지(정기간행물)] - Kirmizis A / 2007 / Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation / Nature 449 : 928 ~ 932
[학술지(정기간행물)] - Bedford MT / 2009 / Protein arginine methylation in mammals:who, what, and why / Mol Cell 33 : 1 ~ 13
[학술지(정기간행물)] - 문은경 / 2011 / Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii / The Korean Journal of Parasitology 49 (4) : 341 ~ 347
[학술지(정기간행물)] - Portela A / 2010 / Epigenetic modifications and human disease / Nat Biotechnol 28 : 1057 ~ 1068
[학술지(정기간행물)] - Kirmizis A / 2007 / Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation / Nature 449 : 928 ~ 932
[학술지(정기간행물)] - Bedford MT / 2009 / Protein arginine methylation in mammals:who, what, and why / Mol Cell 33 : 1 ~ 13
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