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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 491 - 495 (5page)
이용수
초록· 키워드
오류제보하기
Multipurpose contact lens disinfecting solutions (MPDS) are widely used to cleanse and disinfect microorganisms. However, disinfection efficacy of these MPDS against Acanthamoeba cyst remain insufficient. 2, 6-dichlorobenzonitrile (DCB), a cellulose synthesis inhibitor, is capable of increasing the amoebical effect against Acanthamoeba by inhibiting its encystation. In this study, we investigated the possibility of DCB as a disinfecting agent to improve the amoebicidal activity of MPDS against Acanthamoeba cyst. Eight commercial MPDS (from a to h) were assessed, all of which displayed insufficient amoebicidal activity against the mature cysts. Solution e, f, and h showed strong amoebicidal effect on the immature cysts. Amoebicidal efficacy against mature cysts remained inadequate even when the 8 MPDS were combined with 100 μM DCB. However, 4 kinds of MPDS (solution d, e, f, and h) including 100 μM DCB demonstrated strong amoebicidal activity against the immature cysts. The amoebicidal activity of solution d was increased by addition of DCB. Cytotoxicity was absent in human corneal epithelial cells treated with either DCB or mixture of DCB with MPDS. These results suggested that DCB can enhance the amoebicical activity of MPDS against Acanthamoeba immature cyst in vitro.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
[학술지(정기간행물)] - Joslin CE / 2007 / The association of contact lens solution use and Acanthamoeba keratitis / Am J Ophthalmol 144 : 169 ~ 180
[학술지(정기간행물)] - Verani JR / 2009 / National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States / Emerg Infect Dis 15 : 1236 ~ 1242
[학술지(정기간행물)] - Eun-Kyung Moon / 2016 / Efficacy of Korean Multipurpose Contact Lens Disinfecting Solutions against Acanthamoeba castellanii / The Korean Journal of Parasitology 54 (6) : 697 ~ 702
[학술지(정기간행물)] - Turner NA / 1999 / Acanthamoeba spp., antimicrobial agents and contact lenses / Sci Prog 82 : 1 ~ 8
[학술지(정기간행물)] - Jha BK / 2014 / Chloroquine has a cytotoxic effect on Acanthamoeba encystation through modulation of autophagy / Antimicrob Agents Chemother 58 : 6235 ~ 6241
[학술지(정기간행물)] - Verani JR / 2009 / National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States / Emerg Infect Dis 15 : 1236 ~ 1242
[학술지(정기간행물)] - Eun-Kyung Moon / 2016 / Efficacy of Korean Multipurpose Contact Lens Disinfecting Solutions against Acanthamoeba castellanii / The Korean Journal of Parasitology 54 (6) : 697 ~ 702
[학술지(정기간행물)] - Turner NA / 1999 / Acanthamoeba spp., antimicrobial agents and contact lenses / Sci Prog 82 : 1 ~ 8
[학술지(정기간행물)] - Jha BK / 2014 / Chloroquine has a cytotoxic effect on Acanthamoeba encystation through modulation of autophagy / Antimicrob Agents Chemother 58 : 6235 ~ 6241
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