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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 381 - 385 (5page)
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Miniature pig is known to be a most suitable species in xeno-transplantation of human organs. Digestive hormones and enzymes are associated with the function of gastro-intestinal tracts. However, the distribution of digestive hormones and enzymes in gastro-intestinal tract was not known in miniature pig. Thus, we examined the expression of ghrelin, leptin, resistin, CYP3A, and heme-oxygnase 1 mRNA in the digestive organs of miniature pigs. In the present study, ghrelin and leptin mRNA were expressed in the stomach and small intestine but not in large intestine. Resistin mRNA was evidenced in small intestine, liver and kidney. In addition, CYP3A mRNA was remarkably shown in small intestine, liver and kidney. Moreover, heme-oxygenase 1 mRNA was jejunum, duodenum, liver, and kidney. These results may provide the basic research information to xenotransplantation scientists. In conclusion, the ghrelin, leptin, resistin, CYP3A and heme-oxygnase mRNA expression in the digestive organs of miniature pigs were tissue-specific.
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감사의 글
참고문헌
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Aparicio, T. / 2005 / Leptin and Ob-Rb receptor isoform in the human digestive tract during fetal development / J. Clin. Endocrinol. Metab 90 (11) : 6177 ~ 6184
2. [학술지(정기간행물)] - Bertolani, C. / 2006 / Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells / Am. J. Pathol 169 (6) : 2042 ~ 2053
3. [학술지(정기간행물)] - Canaparo, R. / 2007 / Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum / Clin. Exp. Pharmacol. Physiol 34 (11) : 1138 ~ 1144
4. [학술지(정기간행물)] - Chen, X. / 2000 / Alterations in fetal adipose tissue leptin expression correlate with the development of adipose tissue / Biol. Neonate 78 (1) : 41 ~ 47
5. [학술지(정기간행물)] - Coll, A.P. / 2007 / The hormonal control of food intake / Cell 129 (2) : 251 ~ 262
2. [학술지(정기간행물)] - Bertolani, C. / 2006 / Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells / Am. J. Pathol 169 (6) : 2042 ~ 2053
3. [학술지(정기간행물)] - Canaparo, R. / 2007 / Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum / Clin. Exp. Pharmacol. Physiol 34 (11) : 1138 ~ 1144
4. [학술지(정기간행물)] - Chen, X. / 2000 / Alterations in fetal adipose tissue leptin expression correlate with the development of adipose tissue / Biol. Neonate 78 (1) : 41 ~ 47
5. [학술지(정기간행물)] - Coll, A.P. / 2007 / The hormonal control of food intake / Cell 129 (2) : 251 ~ 262
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