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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 555 - 559 (5page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to evaluate gastrointestinal event of solid meal in conscious mature miniature pigs. Mature miniature pigs were divided into two groups; Group 1 was fed a normal finely ground solid diet mixed with barium sulfate and Kolomark<SUP>®</SUP> as radiography marker. Group 2 was fed a normal finely ground solid diet mixed with the same amount of water and Kolomark<SUP>®</SUP> as group 1. Both groups were evaluated the gastrointestinal event of solid meal by plain radiography and image-intensified fluoroscopy. The results of our study showed swallowing movement, gastric emptying time (GET) and motility, total intestinal transit time (TITT), which were made in 2 groups after feeding a test meal. In the group 1, results of radiographic and fluoroscopic findings revealed that gastric emptying commenced within 15 minutes and barium was extensively distributed in the small intestine within 10 hours of ingestion of the test meal, however these could not be confirmed in the group 2. GET was taken within 24 hours and TITT was taken more than 72 hours in both groups. Type I and II gastric contraction wave could not be observed during this study period in both groups. Image-intensified fluoroscopy and radiography using barium sulfate and Kolomark<SUP>®</SUP> enabled estimation of intragastric distribution, gastric motility, GET and TITT of solid meal in conscious mature miniature pigs. These data will be useful for oral administration of therapeutics to miniature pig and human research using the miniature pig model.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (15)
참고문헌 신청
1. [단행본] - Fleming, S.E. / 1986 / Using the pig to study digestion and fermentation in the gut. In Swine in Biomedical Research (Tumbleson, M.E. ed.), 1st ed / Plenum Press : 123 ~ 134
2. [학술지(정기간행물)] - Gardner, N. / 1996 / Development and validation of a pig model for colon-specific drug specific / J. Pharm. Pharmacol 48 : 689 ~ 693
3. [학술지(정기간행물)] - Herich, R. / 2004 / Differences in the development of the small intestine between gnotobiotic and conventionally bred piglets / Berl. Munch. Tierarztl. Wochenschr 117 : 46 ~ 51
4. [학술지(정기간행물)] - Kim, J.E. / 2001 / Clinical usefulness of KolomarkTM, a Korean radioopaque marker for measuring colon transit time / Korean J. Intern. Med 60 (4) : 337 ~ 341
5. [학술지(정기간행물)] - Kararli, T.T. / 1995 / Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals / Biopharm. Drug Dispos 16 (5) : 351380 ~
2. [학술지(정기간행물)] - Gardner, N. / 1996 / Development and validation of a pig model for colon-specific drug specific / J. Pharm. Pharmacol 48 : 689 ~ 693
3. [학술지(정기간행물)] - Herich, R. / 2004 / Differences in the development of the small intestine between gnotobiotic and conventionally bred piglets / Berl. Munch. Tierarztl. Wochenschr 117 : 46 ~ 51
4. [학술지(정기간행물)] - Kim, J.E. / 2001 / Clinical usefulness of KolomarkTM, a Korean radioopaque marker for measuring colon transit time / Korean J. Intern. Med 60 (4) : 337 ~ 341
5. [학술지(정기간행물)] - Kararli, T.T. / 1995 / Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals / Biopharm. Drug Dispos 16 (5) : 351380 ~
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