지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 162 - 167 (6page)
이용수
초록· 키워드
오류제보하기
Due to the shortage of human organ donors for transplant, various studies of xenotransplantation, or the use of animal organs instead of human organs, have been carried out. The organs of porcine are thought to be safer and of a more suitable size for xenotransplantationthan those of nonhuman primates. Understanding the levels of expression of proteins, and their post-translational regulation, would be very practical between different species and among developing stages, though the molecular profiling for xenotransplantation has been rarely studied for porcine, while that of human and rodent is well known. Here, in this present study, we report protein regulation of the developing stages of liver (4-day old neonate, 19-day old piglet and 14-month old adult miniature pigs) using 2-DE and MALDI-TOF. From images of the three different stages, a total of 8 spotswhich were differently regulated were identified, and 5 spots were identified with MALDI-TOF MS. The data presented within this study provides critical direction relating to the development of livers of miniature pigs, which will assist future proteome analysis of the liver, and advance our understanding of the hurdles facing xenotransplantaion.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Junghans P / 2004 / Dietary protein-related changes in hepatic transcription correspond to modifications in hepatic protein expression in growing pigs / J Nutr 134 (1) : 43 ~ 47
2. [학술지(정기간행물)] - Pan TL / 2001 / Proteome analysis in liver transplantation / Transplant Proc 33 : 156 ~
3. [학술지(정기간행물)] - Platt JL / 2000 / Physiologic barriers to xenotransplantation / Transplant Proc 32 (7) : 1547 ~ 1548
4. [학술지(정기간행물)] - Cooper DK / 2002 / Will the pig solve the transplantation backlog? / Annu Rev Med 53 : 133 ~ 147
5. [학술지(정기간행물)] - Tucker A / 2002 / The production of transgenic pigs for potential use in clinical xenotransplantation: baseline clinical pathology and organ size studies / Xenotransplantation 9 (3) : 203 ~ 208
2. [학술지(정기간행물)] - Pan TL / 2001 / Proteome analysis in liver transplantation / Transplant Proc 33 : 156 ~
3. [학술지(정기간행물)] - Platt JL / 2000 / Physiologic barriers to xenotransplantation / Transplant Proc 32 (7) : 1547 ~ 1548
4. [학술지(정기간행물)] - Cooper DK / 2002 / Will the pig solve the transplantation backlog? / Annu Rev Med 53 : 133 ~ 147
5. [학술지(정기간행물)] - Tucker A / 2002 / The production of transgenic pigs for potential use in clinical xenotransplantation: baseline clinical pathology and organ size studies / Xenotransplantation 9 (3) : 203 ~ 208
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UCI(KEPA) : I410-ECN-0101-2014-500-002858155