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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 295 - 298 (4page)
이용수
초록· 키워드
오류제보하기
Miniature pig is known to be a most suitable species in xeno-transplantation of human organs. Autonomic nervous system coupled with G protein plays a pivotal role in the regulation of digestive system. The physiological role of autonomic nervous system may be linked to the interaction of its receptors. However, the distribution of adrenoceptors and muscarinic receptors in digestive system was not known in miniature pig. Thus we examined the expression of adrenoceptors (α1, α2, β1, and β2) and muscarinic receptors (M1, M2, M3) mRNA in the digestive organs of miniature pigs. In the present study, α1, α2, β1, M2, and M3 mRNA expression was evident in stomach but β2 and M1 mRNA expression was not shown in stomach. α1 receptor gene expression was relative high in small intestine and α2 receptor gene expression in large intestine. In addition, β1 receptor mRNA expression was restricted in duodenum, ileum, jejunum and cecum but was not shown in colon and rectum. However, β2 receptor mRNA expression was not evident in these tissues. M1 mRNA expression was evident within in duodenum and ileum, M2 mRNA expression in stomach and small intestine, and M3 mRNA expression in all tissues. Moreover, α1, α2, β1 and M3 was evident in pancreas. In conclusion, adrenoceptors and muscarinic receptors are tissue-specifically expressed in digestive organs of miniature pigs.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Fulop, K / 2005 / Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence 528 : 150 ~ 157
2. [학술지(정기간행물)] - Grundy, D / 2007 / Enteric nervous system 23 (2) : 121 ~ 126
3. [학술지(정기간행물)] - Hamrouni, A.M / 2006 / Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors 26 (3) : 275 ~ 284
4. [학술지(정기간행물)] - Lambrecht / 1988 / Different binding properties of muscarinic M2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa : 630 ~ 94 637
5. [학술지(정기간행물)] - Hirota, C.L / 2006 / Cholinergic regulation of epithelial ion transport in the mammalian intestine 149 (5) : 463 ~ 479
2. [학술지(정기간행물)] - Grundy, D / 2007 / Enteric nervous system 23 (2) : 121 ~ 126
3. [학술지(정기간행물)] - Hamrouni, A.M / 2006 / Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors 26 (3) : 275 ~ 284
4. [학술지(정기간행물)] - Lambrecht / 1988 / Different binding properties of muscarinic M2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa : 630 ~ 94 637
5. [학술지(정기간행물)] - Hirota, C.L / 2006 / Cholinergic regulation of epithelial ion transport in the mammalian intestine 149 (5) : 463 ~ 479
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