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논문 기본 정보

자료유형
학술저널
저자정보
Liu, Jin-Fei (Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Southern Medical University) Xie, Hao-Jun (Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University) Cheng, Tian-Ming (Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Southern Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호
발행연도
2013.1
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7,271 - 7,275 (5page)

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Objective: To investigate the association between the gene polymorphisms of angiotensin-converting enzyme (ACE) and digestive system cancer risk. Method: A search was performed in Pubmed, Medline, ISI Web of Science and Chinese Biomedical (CBM) databases, covering all studies until Sep 1st, 2013. Statistical analysis was performed by using Revman5.2 and STATA 12.0. Results: A total of 15 case-control studies comprising 2,390 digestive system cancer patients and 9,706 controls were identified. No significant association was found between the I/D polymorphism and digestive cancer risk (OR=0.93, 95%CI = (0.75, 1.16), P=0.53 for DD+DI vs. II). In the subgroup analysis by ethnicity and cancer type, no significant associations were found for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated a lack of associations between this polymorphism and digestive system cancer risks. Conclusions: This meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of digestive system cancer.

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