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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제2호
- 발행연도
- 2015.1
- 수록면
- 188 - 193 (6page)
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초록· 키워드
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Objective: There is growing evidence for a gut-brain connection associated with autism spectrum disorders (ASDs). This suggests a potential benefit from introduced digestive enzymes for children with ASD.
Methods: We performed a double-blind, randomized clinical trial on 101 children with ASD (82 boys and 19 girls) aged from 3 to 9 years. ASD patients were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) diagnostic criteria. Structured interviews of at least one hour each both with the parents and the child were performed. Later on, another two hours-session was conducted applying the Childhood Autism Rating Scale (CARS).
ASD patients were randomized to receive digestive enzymes or placebo.
Results: The ASD group receiving digestive enzyme therapy for 3 months had significant improvement in emotional response, general impression autistic score, general behavior and gastrointestinal symptoms. Our study demonstrated the usefulness of digestive enzyme in our population of ASD patients.
Conclusion: Digestive enzymes are inexpensive, readily available, have an excellent safety profile, and have mildly beneficial effects in ASD patients. Depending on the parameter measured in our study, we propose digestive enzymes for managing symptoms of ASD. Digestive enzyme therapy may be a possible option in treatment protocols for ASD in the future.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Adams JB. / / Summary of dietary, nutritional, and medical treatments for autism based on over 150 published research studies
Adams JB. / 2011 / Effect of a vitamin/mineral supplement on children and adults with autism / BMC Pediatr 11 : 111 ~
American Psychiatric Association. / 2000 / Diagnostic and statistical manual of mental disorders : DSM-IV-TR / American Psychiatric Association
Brudnak MA. / 2002 / Enzyme-based therapy for autism spectrum disorders-is it worth another look? / Med Hypotheses 58 : 422 ~ 428
Buie T. / 2010 / Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report / Pediatrics 125 (Suppl 1) : S1 ~ S18
Adams JB. / 2011 / Effect of a vitamin/mineral supplement on children and adults with autism / BMC Pediatr 11 : 111 ~
American Psychiatric Association. / 2000 / Diagnostic and statistical manual of mental disorders : DSM-IV-TR / American Psychiatric Association
Brudnak MA. / 2002 / Enzyme-based therapy for autism spectrum disorders-is it worth another look? / Med Hypotheses 58 : 422 ~ 428
Buie T. / 2010 / Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report / Pediatrics 125 (Suppl 1) : S1 ~ S18
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