지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Fibrates are a class of hypolipidemic agents whose effects are mediated by activation of a specific transcription factor called the peroxisome proliferator-activated receptor α (PPARα). PPARα regulates the pathways of lipid catabolism such as fatty acid oxidation and the triglyceride metabolism, resulting in the treatment of hyperlipidemia. The decreased levels of plasma triglycerides by fibrates are responsible for hypertrophy and hyperpalsia of adipose cells. To determine whether fenofibrate regulates adipogenesis in female C57BL/6J mice, we measured the effects of fenofibrate on not only body weight, adipose tissue mass and serum triglycerides, but also the histology of adipose tissue and the expression of adipocyte marker genes. Fenofibrate did not inhibit high fat diet-induced increases in body weight, adipose tissue mass and serum triglycerides. Furthermore, fenofibrate did not cause the changes in the size and number of adipocytes and the expression of adipocyte-specific genes such as leptin and TNFα. Therefore, this study demonstrates that fenofibrate does not affect adipogenesis in female mice.
목차
영어 초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Sexually Dimorphic Control of Obesity and Skeletal Muscle Lipid Metabolism by Fenofibrate
대한의생명과학회지
2013 .03
-
Fenofibrate Inhibits Visceral Adiposity by Inhibiting UCPs in C57BL/6J Mice Fed on a High Fat Diet
대한의생명과학회지
2012 .12
-
Fenofibrate 투여와 신장 기능의 변화: 무엇을 어떻게 고려해야 할까
대한내과학회지
2014 .01
-
고중성지방혈증 환자에서 단기간의 Fenofibrate 투여가 혈중크레아티닌 농도에 미치는 영향
대한내과학회지
2014 .01
-
페노피브레이트 유연물질 표준품 대체시험법 개발
약학회지
2015 .01
-
Peroxisome Proliferator-activated Receptor γ Is Not Associated with Adipogenesis in Female Mice
대한의생명과학회지
2008 .09
-
Fenofibrate: direct attenuating effects on tumor growth
Radiation oncology journal : ROJ
2013 .01
-
Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver
Annals of Hepato-Biliary-Pancreatic Surgery
2013 .08
-
식단에 따르는 페노피브레이트 서방성 캡슐의 1회 경구 투여 후 약물동태학 및 약물동력학의 평가
한국임상약학회지
2005 .01
-
Regulation of PPAR and SREBP-1C Through Exercise in White Adipose Tissue of Female C57BL/6J Mice
대한의생명과학회지
2012 .09
-
Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
17β-estradiol Represses White Adipose Tissue Metabolism by Inhibiting PPARγ in High Fat Diet-induced Obese Female Ovariectomized Mice
대한의생명과학회지
2009 .09
-
I L - 1β에 의해 활성화 된 혈관내피 세포들에서 f e n o f i b r a t e에 의한 IL-6, IL-8, 그리고 V C A M - 1의 분비 및 발현 억제에 대한 효과
대한뇌졸중학회지
2000 .01
-
In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
고중성지방혈증에서 fenofibrate에 대한 acipimox의 효과 비교
한국임상약학회지
2012 .01
-
Repression of PPARγ Activity on Adipogenesis by 17β-estradiol in Differentiated 3T3-L1 Cell
대한의생명과학회지
2009 .09
-
Morphological Changes in Adipose and Liver Tissues by 17β-estradiol in Female Ovariectomized C57BL/6J Mice
대한의생명과학회지
2007 .06
-
Swim Training Improves Fitness in High Fat Diet-fed Female Mice
대한의생명과학회지
2010 .09
-
17β-estradiol Prevents the Expression of CEBPα-mediated Adipocyte Marker Genes in Female Ovariectomized C57BL/6 Mice
대한의생명과학회지
2008 .09
-
HDL Cholesterol Reduction during Rosiglitazone and Fenofibrate Treatment in a Type 2 Diabetes Mellitus Patient with Dyslipidemia
Annals of Laboratory Medicine
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-017354069