지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 151 - 159 (9page)
이용수
초록· 키워드
오류제보하기
The peroxisome proliferator-activated receptor α (PPARα) is a nuclear transcription factor that plays a central role in lipid metabolism and obesity. Exercise also is a powerful modifier of the manifestations of the lipid metabolism and obesity in animal models and humans with obesity and metabolic syndrome. However, effects of exercise on lipid metabolism and obesity in normal-weight younger female subjects, having functional ovaries and not metabolic disease, remain unexplained. To explore the effects of exercise on the development of obesity and its molecular mechanism in high fat diet-fed female C57BL/6J mice, we experimented the effects of swim training on body weight, adipose tissue mass, serum lipid levels, morphological changes of adipocytes and the expression of PPARα target genes involved in fat oxidation in skeletal muscle tissue of female C57BL/6J mice. Swim-trained mice had significantly decreased body weight, adipose tissue mass, serum triglycerides compared with female control mice. Histological studies showed that swim training significantly decreased the average size of adipoctyes in parametrial adipose tissue. Swim training did not affect the expression of PPARα mRNA in skeletal muscle. Concomitantly, swim training did not increase mRNA levels of PPARα target genes responsible for fatty acid β-oxidation, such as carnitine palmitoyltransferase 1, medium chain acyl-CoA dehydrogenase, enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase, and thiolase in skeletal muscle. In conclusion, these results indicate that swim training regulates lipid metabolism and obesity in high fat diet fed-female mice although swim training did not increase mRNA levels of PPARα target genes involved in fatty acid β-oxidation in skeletal muscle, suggesting that swim training may prevent obesity and improve fitness through other mechanisms in female with functioning ovaries, not through the activation of skeletal muscle PPARα.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (42)
참고문헌 신청
1. [학술지(정기간행물)] - Auwerx J / 1996 / Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR / Atherosclerosis 124 : S29 ~ S37
2. [학술지(정기간행물)] - Bourgeois F / 1983 / Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice / Br J Nutr 49 : 17 ~ 26
3. [학술지(정기간행물)] - Bray GA / 2003 / Risks of obesity / Endocrinol Metab Clin North Am 32 : 787 ~ 804
4. [학술지(정기간행물)] - Chaput E / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight / Biochem Biophys Res Commun 271 : 445 ~ 450
5. [학술지(정기간행물)] - Costet P / 1998 / Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis / J Biol Chem 273 : 29577 ~ 29585
2. [학술지(정기간행물)] - Bourgeois F / 1983 / Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice / Br J Nutr 49 : 17 ~ 26
3. [학술지(정기간행물)] - Bray GA / 2003 / Risks of obesity / Endocrinol Metab Clin North Am 32 : 787 ~ 804
4. [학술지(정기간행물)] - Chaput E / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight / Biochem Biophys Res Commun 271 : 445 ~ 450
5. [학술지(정기간행물)] - Costet P / 1998 / Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis / J Biol Chem 273 : 29577 ~ 29585
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differential Regulation of Obesity by Swim Training in Female Sham-operated and Ovariectomized Mice
대한의생명과학회지
2011 .03
-
Regulation of PPAR and SREBP-1C Through Exercise in White Adipose Tissue of Female C57BL/6J Mice
대한의생명과학회지
2012 .09
-
Liver PPARα and UCP2 are Involved in the Regulation of Ovariectomy-Induced Adiposity and Steatosis by Swim Training
대한의생명과학회지
2010 .12
-
Sexually Dimorphic Control of Obesity and Skeletal Muscle Lipid Metabolism by Fenofibrate
대한의생명과학회지
2013 .03
-
17β-estradiol Represses White Adipose Tissue Metabolism by Inhibiting PPARγ in High Fat Diet-induced Obese Female Ovariectomized Mice
대한의생명과학회지
2009 .09
-
Peroxisome Proliferator-activated Receptor γ Is Not Associated with Adipogenesis in Female Mice
대한의생명과학회지
2008 .09
-
Troglitazone Lowers Serum Triglycerides with Sexual Dimorphism in C57BL/6J Mice
대한의생명과학회지
2006 .06
-
수영운동 치료가 고지방식 투여 SD-Rat의 지방간에 미치는 영향
대한물리치료사학회지
1999 .01
-
Prophylactic effects of swimming exercise on autophagy-induced muscle atrophy in diabetic rats
Laboratory Animal Research
2012 .09
-
Effects of Fenofibrate on Adipogenesis in Female C57BL/6J Mice
대한의생명과학회지
2005 .03
-
Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver
Annals of Hepato-Biliary-Pancreatic Surgery
2013 .08
-
Repression of PPARγ Activity on Adipogenesis by 17β-estradiol in Differentiated 3T3-L1 Cell
대한의생명과학회지
2009 .09
-
Anti-obesity Effects of Heloniopsis orientalis through Controlling Lipid Metabolism in High-fat induced Obesity Mouse
한국실험동물학회 학술발표대회 논문집
2009 .04
-
Expression of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$ and PPAR-${\gamma}$ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
Korean journal of pediatrics
2013 .01
-
Anti-obesity Effects of Korean Red Ginseng Extract in C57BL6/J Mice fed with High Fat Diet
고려인삼학회 학술대회
2009 .05
-
Association of the PPAR-γ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics
PSYCHIATRY INVESTIGATION
2014 .01
-
암컷 hGHTg 비만 쥐에서 경신해지환(輕身解脂丸) (GGT1)에 의한 비만관련 유전자 mRNA 발현의 변화
동의생리병리학회지
2006 .01
-
Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications
Yonsei Medical Journal
2013 .01
-
Morphological Changes in Adipose and Liver Tissues by 17β-estradiol in Female Ovariectomized C57BL/6J Mice
대한의생명과학회지
2007 .06
-
Anti-obesity effects of Rapha diet® preparation in mice fed a high-fat diet
Laboratory Animal Research
2012 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-510-003686579