지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 171 - 177 (7page)
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This study investigated whether increased adiposity is prevented by estrogen replacement in female ovariectomized (OVX) C57BL/6J mice, an animal model of human menopause and whether these metabolic changes reflect the inhibitory action of estrogen on peroxisome proliferator-activated receptor γ (PPARγ)-regulated gene expression. Treatment of 17β-estradiol for the last one week of the experiment decreased high fat diet-induced body weight gain and white adipose tissue mass compared to OVX control mice. Histological analysis showed that administration of 17β-estradiol to mice decreased the size of adipocytes in parametrial adipose tissue versus OVX control mice. In addition, 17β-estradiol reduced the adipose expression of PPARγ as well as PPARγ target genes such as adipocyte fatty acid binding protein and tumor necrosis factor α. These results suggest that 17β-estradiol may inhibit adiposity through reducing the PPARγ activities in female OVX mice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-510-018855958