지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 355 - 361 (7page)
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We investigated to verify whether the PPARα agonist fenofibrate regulates adipose tissue metabolism and to determine the molecular mechanism involved in this regulation. After male mice (C57BL/6J) received a high fat diet with or without fenofibrate for 6 weeks, the effects of fenofibrate on not only adipose tissue weight, visceral adipocyte size, serum lipid and glucose levels, but also the expression of uncoupling proteins (UCPs). Mice given a fenofibrate-supplemented high fat diet showed reduced both visceral and subcutaneous adipose tissue weights versus high fat diet-fed animals. The size of visceral adipocytes was significantly decreased by fenofibrate treatment. The administration of fenofibrate resulted in decreased serum levels of triglycerides, free fatty acids, and glucose. Moreover, fenofibrate up-regulated mRNA levels of visceral adipose tissue UCP2 and skeletal muscle UCP3. Therefore, our results suggest that the increases in the expression of UCPs by fenofibrate seem to suppress diet-induced visceral adiposity as well as severe hypertriglyceridemia and hyperglycemia in male mice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
Acín A / 1999 / Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene / Biochem Biophys Res Commun 258:278~283
Boden G / 1994 / Mechanisms of fatty acid-induced inhibition of glucose uptake / J Clin Invest 93:2438~2446
Bourgeois F / 1983 / Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice / Br J Nutr 49:17~26
Cabrero A / 1999 / Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats / Biochem Biophys Res Commun 260:547~556
Cabrero A / 2000 / Peroxisome proliferator-activated receptor α (PPARα) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes / Arch Biochem Biophys 380:353~359
Boden G / 1994 / Mechanisms of fatty acid-induced inhibition of glucose uptake / J Clin Invest 93:2438~2446
Bourgeois F / 1983 / Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice / Br J Nutr 49:17~26
Cabrero A / 1999 / Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats / Biochem Biophys Res Commun 260:547~556
Cabrero A / 2000 / Peroxisome proliferator-activated receptor α (PPARα) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes / Arch Biochem Biophys 380:353~359
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UCI(KEPA) : I410-ECN-0101-2014-510-000614302