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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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We examined the effects of food on pharmacokinetic and pharmacodynamic properties of fenofibrate released from sustained-release (SR) capsule as therapy for hypolipidemia. Twenty-four healthy volunteers were used in 3 × 3 crossover pharmacokinetic and pharmacodynamic study; Additional six volunteers were used as a control group(i.e., no fenofibrate administration). A single dose of fenofibrate (SR capsule, 250 mg) was administered on three occasions: after overnight fasting, after consumption of a standard breakfast, and after a high-fat breakfast. Serial blood samples were collected for the next 72 hours. Plasma fenofibric acid concentrations were measured by high performance liquid chromatography, and pharmacokinetic parameters were calculated using ADAPT II program. Plsama triglyceride concentrations
were measured by blood chemistry analyzer (CH-100). The pharmacokinetic parameters were significantly affected by food intake. The high-fat breakfast affected the rate of absorption of fenofibrate more than did the standard breakfast and fasted conditions. Plasma concentrations of triglyceride at 24 hours decreased significantly after the administration of fenofibrate compared with the concentration at 0 hours(P<0.05). In healthy volunteers, the bioavailability of fenofibrate was greater when administered via sustained-release capsules immediately after the consumption of food than after fasting condition
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참고문헌 (12)
참고문헌 신청
Balfour JA / 1990 / Fenofibrate 40 : 260 ~ 90
Genest / jcardiovascpharmacol2000 / Effect of micronizedfenofibrate on plasma lipoprotein levels and hemostaticparameters of hypertriglyceridemic patients with lowlevels of h
Gonzalez FJ / 1998 / Mechanism ofaction of the nongenotoxic peroxisome proliferator-activatedreceptor-alpha 90 : 1702 ~ 9
Guivarc’h PH / Ther2004 / A new fenofibrateformulation:results of six single-dose clinical studies ofbioavailability under fed and fasting conditions 26 : 1456 ~ 69
Hans UK / 1987 / Am J Med 83 (5) : 9 ~ 20
Genest / jcardiovascpharmacol2000 / Effect of micronizedfenofibrate on plasma lipoprotein levels and hemostaticparameters of hypertriglyceridemic patients with lowlevels of h
Gonzalez FJ / 1998 / Mechanism ofaction of the nongenotoxic peroxisome proliferator-activatedreceptor-alpha 90 : 1702 ~ 9
Guivarc’h PH / Ther2004 / A new fenofibrateformulation:results of six single-dose clinical studies ofbioavailability under fed and fasting conditions 26 : 1456 ~ 69
Hans UK / 1987 / Am J Med 83 (5) : 9 ~ 20
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