지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background/Aims: Previous studies have reported that fenofibrate therapy increases blood creatinine levels. The aim of this studywas to evaluate the effect of fenofibrate therapy on the renal function in patients with hypertriglyceridemia and to determine theparameters associated with changes in renal functions.
Methods: This prospective study enrolled 86 hypertriglyceridemic patients (triglycerides ≥ 200 mg/dL) who were divided into twogroups: the fenofibrate group (n = 43), who received 160 mg of fenofibrate, and the control group (n = 43). Lipid profiles and renalfunction were measured at the beginning of the study and after 2 months.
Results: The estimated glomerular filtration rate (eGFR) decreased in the fenofibrate group (p < 0.001), but did not change in thecontrol group (p = 0.80). Accordingly, the decrease was more pronounced in the fenofibrate group than the control group (-18.6 ±8.6 vs. 0.9 ± 9.6%, respectively; p < 0.001). Changes in serum creatinine (p < 0.001) and blood urea nitrogen (p < 0.005) levels weresimilar to those of eGFR. In a stepwise linear regression analysis, the percent change in creatinine was independently associatedwith fenofibrate therapy (r = 0.71; p < 0.001) and old age (r = 0.27; p < 0.05) in all patients. In the fenofibrate group, percent changein creatinine was associated with age (r = -0.51; p < 0.001) and smoking (r = 0.42; p < 0.005), while percent change was associatedwith body mass index (r = 0.31; p < 0.05) in the control group. Elevation of creatinine by 20% or more was associated withfenofibrate therapy (p < 0.001) and old age (p < 0.005) in all patients, and with old age (p < 0.001) in the fenofibrate group.
Conclusions: Short-term fenofibrate therapy significantly impaired the renal function of hypertriglyceridemic patients, and thiseffect was more pronounced in elderly patients. This finding suggests that creatinine levels should be followed in patients receivingfenofibrate therapy.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Abourbih S / 2009 / Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review / Am J Med 122 : 962.e1 ~ 962.e8
Angeles C / 2004 / Fenofibrateassociated reversible acute
Ansquer JC / 2008 / Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people / Am J Kidney Dis 51 : 904 ~ 913
Broeders N / 2000 / Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent / Nephrol Dial Transplant 15 : 1993 ~ 1999
Cho JH / 2013 / Effect of fenofibrate therapy on blood creatinine levels in patients with hypertension and hypertriglyceridemia / J Lipid Atheroscler 2 : 19 ~ 26
Angeles C / 2004 / Fenofibrateassociated reversible acute
Ansquer JC / 2008 / Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people / Am J Kidney Dis 51 : 904 ~ 913
Broeders N / 2000 / Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent / Nephrol Dial Transplant 15 : 1993 ~ 1999
Cho JH / 2013 / Effect of fenofibrate therapy on blood creatinine levels in patients with hypertension and hypertriglyceridemia / J Lipid Atheroscler 2 : 19 ~ 26
이 논문의 저자 정보
최근 본 자료
댓글(0)
0