Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

Liu, Jia; Ge, Yang-Yang; Zhu, Hong-Cheng; Yang, Xi; Cai, Jing; Zhang, Chi; Lu, Jing; Zhan, Liang-Liang; Qin, Qin; Yang, Yan; Yang, Yue-Hua; Zhang, Hao; Chen, Xiao-Chen; Liu, Zhe-Ming; Ma, Jian-Xin; Cheng, Hong-Yan; Sun, Xin-Chen

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자료유형: 학술저널

저자정보: Liu, Jia (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Ge, Yang-Yang (Department of Radiation Oncology, The Affiliated Tumor Hospital of Nantong University) Zhu, Hong-Cheng (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Yang, Xi (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Cai, Jing (Department of Radiation Oncology, The Affiliated Tumor Hospital of Nantong University) Zhang, Chi (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Lu, Jing (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Zhan, Liang-Liang (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Qin, Qin (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Yang, Yan (Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University) Yang, Yue-Hua (Department of Radiation Oncology, The First Affiliated H) Zhang, Hao Chen, Xiao-Chen Liu, Zhe-Ming Ma, Jian-Xin Cheng, Hong-Yan Sun, Xin-Chen

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제16호

발행연도: 2014.1

수록면: 6,649 - 6,655 (7page)

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Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.

#Fenofibrate #HNSCC #cell cycle #radiotherapy

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Liu, Jia

소속기관 Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University