지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience Vol.22 No.1
- 발행연도
- 2024.2
- 수록면
- 139 - 150 (12page)
- DOI
- 10.9758/cpn.23.1084
이용수
초록· 키워드
오류제보하기
Objective: Recent evidence suggests that oxidative stress contributes to the pathophysiology of schizophrenia. This study aimed to compare thiol-disulphide homeostasis in acute and stable phases of schizophrenia for the first time.
Methods: Among the patients with schizophrenia, 61 in the acute-phase and 61 in the stable phase of their illness were enrolled in the study. Native thiol (NT), total thiol (TT), disulphide (SS), disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol for thiol-disulphide homeostasis were compared between the groups. The Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive/Negative Symptoms (SAPS/SANS), Clinical Global Impression Severity Scale (CGI-S), Barnes Akathisia Rating Scale, and Simpson-Angus Scale were used to assess symptoms.
Results: After controlling for age, sex, body mass index, and smoking status there were significant differences in NT, TT, SS/NT, SS/TT, and NT/TT, but not SS. Thiol/disulphide homeostasis has shifted in favour of the oxidative side in patients with acute-phase compared to that in stable schizophrenia. BPRS, SAPS, and CGI-S scores were significantly correlated with all six thiol-disulphide parameters, but not SANS, when controlling for age and sex. Significant receiver operating characteristic (ROC) curves were obtained for all thiol-disulphide homeostasis parameters. Discriminant analy sis was found to be statistically significant in discriminating between groups.
Conclusion: These results show that oxidative status increases thiol-disulphide homeostasis in patients with acute-phase schizophrenia compared to those with stable schizophrenia. These findings suggest that thiol-disulphide parameters can be used as biomarkers for the acute exacerbation of schizophrenia.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder
Clinical Psychopharmacology and Neuroscience
2022 .05
-
Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Clinical Psychopharmacology and Neuroscience
2020 .01
-
Dynamic Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Adult Attention Deficit Hyperactivity Disorder
Clinical Psychopharmacology and Neuroscience
2021 .11
-
Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis
Investigative and Clinical Urology
2019 .01
-
Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome
Obstetrics & Gynecology Science
2024 .07
-
Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?
Journal of Korean Medical Science
2017 .01
-
Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .09
-
Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants
생체재료학회지
2015 .09
-
Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver
Toxicological Research
2016 .04
-
Synthesis of <sup>125</sup>I-labeled thiol-reactive prosthetic group for site-specific radiolabeling of human serum albumin
대한방사성의약품학회지
2018 .01
-
Thymoquinone Prevents Myocardial and Perivascular Fibrosis Induced by Chronic Lipopolysaccharide Exposure in Male Rats: Thymoquinone and Cardiac Fibrosis
Journal of Pharmacopuncture
2018 .01
-
The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study
예방의학회지
2016 .01
-
Liver Dysfunction and Oxidative Stress in Streptozotocin-Induced Diabetic Rats: Protective Role of Artemisia Turanica
Journal of Pharmacopuncture
2019 .01
-
Acute intradialytic exercise and oxidative stress in hemodialysis patients
Kidney Research and Clinical Practice
2015 .01
-
Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis
한국실험동물학회 학술발표대회 논문집
2022 .01
-
SYNTAX Score and SYNTAX Score II Can Predict the Clinical Outcomes of Patients with Left Main and/or 3-Vessel Disease Undergoing Percutaneous Coronary Intervention in the Contemporary Cobalt-Chromium Everolimus-Eluting Stent Era
Korean Circulation Journal
2020 .01
-
Oxidative Stress-Induced Apoptosis in Chronic Myelogenous Leukemia K562 Cells by an Active Compound from the Dithio-Carbamate Family
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22e26-month-old C57BL/6J mice
Journal of Ginseng Research
2022 .11
-
Amisulpride Switching in Schizophrenic Patients Who Showed Suboptimal Effect and/or Tolerability to Current Antipsychotics in a Naturalistic Setting: An Explorative Study
Clinical Psychopharmacology and Neuroscience
2016 .01
최근 본 자료
댓글(0)
0