지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,588 - 1,594 (7page)
이용수
초록· 키워드
오류제보하기
Familial Mediterranean fever (FMF) is a chronic autoinflammatory condition characterized by fever attacks and recurrent polyserositis. Subclinical inflammation that persists during attack-free periods can result in oxidative stress (OS) damage. Thiol groups bind to reactive oxygen radicals and protect cells and tissues from OS damage. The aim of this study was to investigate the relationship between thiol-disulfide balance and colchicine resistance in FMF patients during an attack or attack-free period. A newly developed spectrophotometric method was used to measure native thiol (NT) and disulfide (DS) levels in FMF patients and an age-sex matched group of healthy controls. NT and DS levels were compared in FMF patients 1) with vs. without colchicine resistance; and 2) during an attack (FMF-AP) vs. attack-free period (FMF-AFP). A total of 118 FMF patients and 60 healthy controls were studied. NT (P < 0.001) and total thiol (TT) (P < 0.001) levels in FMF patients were significantly lower compared to healthy controls. NT (P = 0.030) and TT (P = 0.010) levels of FMF-AP patients were significantly lower than that of FMF-AFP patients. FMF-AP patients had significantly higher DS levels than FMF-AFP patients (P = 0.039). Compared to FMF patients without colchicine resistance, elevated levels of DS (P = 0.019) but not NT (P = 0.620) and TT (P = 0.718) were found in those with colchicine resistance. Thiol-disulfide homeostasis is altered in FMF patients during an attack period and this imbalance may be associated with colchicine resistance.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Gershoni-Baruch R / 2002 / The differential contribution of MEFV mutant alleles to the clinical profile of familial Mediterranean fever / Eur J Hum Genet 10:145~149
구교연 / 2012 / The First Case of Familial Mediterranean Fever Associated with Renal Amyloidosis in Korea / Yonsei Medical Journal 53(2):454~458
Kim ML / 2015 / Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β / J Exp Med 212:927~938
Chae JJ / 2011 / Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice / Immunity 34:755~768
Ben-Zvi I / 2011 / Chronic inflammation in FMF: markers, risk factors, outcomes and therapy / Nat Rev Rheumatol 7:105~112
구교연 / 2012 / The First Case of Familial Mediterranean Fever Associated with Renal Amyloidosis in Korea / Yonsei Medical Journal 53(2):454~458
Kim ML / 2015 / Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β / J Exp Med 212:927~938
Chae JJ / 2011 / Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice / Immunity 34:755~768
Ben-Zvi I / 2011 / Chronic inflammation in FMF: markers, risk factors, outcomes and therapy / Nat Rev Rheumatol 7:105~112
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