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논문 기본 정보

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저자정보
Berra Sen (Department of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Senem Gonultas (Department of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Ceren Albayrak (Department of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Sevval Temur (Department of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Ilgar Acar (Department of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Beyza Nur Ozkan (Department of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Havva Sevde Islek (Department of Obstetrics and Gynecology, Bezmialem Vakif University) Muserref Banu Yilmaz (Department of Obstetrics and Gynecology, University of Health Sciences Turkey, Zeynep Kamil Women and Children's Diseases Training and Research Hospital) Ebru Kale (Department of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine) Eray Metin Guler (Department of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science Vol.67 No.4
발행연도
2024.7
수록면
414 - 420 (7page)
DOI
10.5468/ogs.24031

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Objective Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder characterized by hyperandrogenism, hyperinsulinemia, and insulin resistance. The prevalence of PCOS is increasing worldwide. Although the etiology of this disease is currently unknown, it is thought to be closely related to inflammation and oxidative stress. Our study aimed to compare patients have PCOS to healthy volunteers and assess the changes in oxidative stress and inflammatory parameters in these patients. Methods Thirty patients between the ages of 18-45 diagnosed with PCOS and 30 healthy volunteers with the same demographic characteristics were included in this study. Clinical parameters were measured using immunoassays. Oxidative stress biomarkers, total oxidant (TOS), total antioxidant (TAS), total thiol (TT), and native thiol (NT) levels were measured using photometric methods according to Erel’s method. The dynamic disulfide level (DIS) and oxidative stress index (OSI) were calculated using mathematical equations. Among the inflammatory parameters, values for interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured photometrically using commercially purchased kits. Results Moreover, TT and NT levels were lower in patients with PCOS compared to those in the healthy group statistically significantly (P<0.001). In addition, TAS, TOS, OSI, DIS, IL-1β, IL-6, and TNF-α levels were identified to be significantly higher in the patients with PCOS than those in the healthy group (P<0.001). Conclusion Evaluation of oxidative stress and clinical parameters used in the follow-up may be beneficial for the disease.
#Inflammation #Oxidative stress #Polycystic ovary syndrome #Reactive oxygen species #Disulfide

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