지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 174 - 183 (10page)
- DOI
- 10.1186/s40824-015-0041-3
이용수
초록· 키워드
오류제보하기
Background: The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals. Results: Most constituents were found in extracts of OSTE+, whereas only initiators were found in OSTE+H2O extracts. The detected levels of each chemical found in the LC-MS and the GC-MS analysis were below the toxicity level when compared to MTT assays of all the individual chemicals, except for one of the initiators that had an IC50 value close to the detected levels. Conclusion: Our notion is that the toxicity of OSTE+ was caused by one of the initiators, by impurities in the constituents or by synergistic effects of low doses of leaked chemicals. However, our conclusion is that if OSTE+ is incubated for one week in water, OSTE+ is not cytotoxic and suitable for further in vivo studies.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Rodriguez-Oroz MC. / 2005 / Bilateral deep brain stimulation in Parkinson’s disease : a multicentre study with 4 years follow-up / Brain 128:2240~2249
Vlamings R. / 2007 / High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats / Neuroscience 148:815~823
Schwartz AB. / 2004 / Cortical neural prosthetics / Annu Rev Neurosci 27:487~507
Nandi D. / 2002 / Thalamic field potentials during deep brain stimulation of periventricular gray in chronic pain / Pain 97:47~51
Blau A. / 2011 / Flexible, allpolymer microelectrode arrays for the capture of cardiac and neuronal signals / Biomaterials 32:1778~1786
Vlamings R. / 2007 / High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats / Neuroscience 148:815~823
Schwartz AB. / 2004 / Cortical neural prosthetics / Annu Rev Neurosci 27:487~507
Nandi D. / 2002 / Thalamic field potentials during deep brain stimulation of periventricular gray in chronic pain / Pain 97:47~51
Blau A. / 2011 / Flexible, allpolymer microelectrode arrays for the capture of cardiac and neuronal signals / Biomaterials 32:1778~1786
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