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논문 기본 정보

자료유형
학술저널
저자정보
Faruk Kurhan (Van Yuzuncu Yil University) Hamit Hakan Alp (독립연구자)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
발행연도
2021.11
수록면
731 - 738 (8page)
DOI
10.9758/cpn.2021.19.4.731

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Objective: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide homeostasis as well as oxidative DNA damage levels in adult ADHD patients and to compare them with the results of healthy control subjects. Methods: The study was inclusive of forty-nine patients who were diagnosed with adult ADHD, as well as thirty-three healthy volunteers to be used as the control group. The diagnosis of the patients was conducted according to the DSM-5 diagnostic criteria. Blood were stored under appropriate laboratory conditions. For the purpose of detecting the oxidative DNA damage level, an extraction of genomic DNA from leukocytes was carried out, and furthermore the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), apart from deoxyguanosine, were measured accordingly. Results: Total thiol and the native thiol levels were observed to be statistically lower in adult ADHD patients as compared to the subjects in the healthy control group (p = 0.001). It was observed that the disulfide levels were higher in adult ADHD patients as compared to the healthy control subjects (p = 0.001). In addition, the levels of 8-OHdG, which are considered as a marker for assessing DNA damage, were found to be significantly lower in the control group as compared to the adult ADHD patients (p = 0.001). Conclusion: It was observed that the thiol/disulfide homeostasis had shifted towards disulfide, and 8-OHdG levels were increased in adult ADHD patients.
#Adult ADHD #Thiol disulfide #Oxidative DNA damage.

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참고문헌 (49)

참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders: DSM-5 / American Psychiatric Pub google schola Wolraich ML / 2019 / Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents / Pediatrics 144:e20192528 google schola Barkley RA / 2002 / The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder / J Abnorm Psychol 111:279~289 google schola Meza JI / 2019 / Stigma and attention-deficit/hyperactivity disorder : negative perceptions and anger emotional reactions mediate the link between active symptoms and social distance / Atten Defic Hyperact Disord 11:373~382 google schola Smalley SL / 2000 / Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder / J Am Acad Child Adolesc Psychiatry 39:1135~1143 google schola

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