Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Gamze Erzin; Guven Ozkaya; Canan Topcuo?lu; Rabia Nazik Yuksel; Ozcan Erel; Emine Feyza Yurt; Erol Goka; Sinan Guloksuz

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자료유형: 학술저널

저자정보: Gamze Erzin (Ankara Dı?kapı Yıldırım Beyazıt Training and Research Hospital) Guven Ozkaya (Bursa Uluda? University) Canan Topcuo?lu (Bilkent City Hospital) Rabia Nazik Yuksel (Bilkent City Hospital) Ozcan Erel (Bilkent City Hospital) Emine Feyza Yurt (Bilkent City Hospital) Erol Goka (Bilkent City Hospital) Sinan Guloksuz (Maastricht University Medical Center)

저널정보: 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제3호

발행연도: 2020.1

수록면: 395 - 401 (7page)

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Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/ native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

#Oxidative stress #Bipolar depression #Unipolar depression #Mood disorder.

참고문헌 (42)

참고문헌 신청

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Gamze Erzin

소속기관 Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital

주요연구분야 의약학 > 임상의학 > 정신과학

논문수 3 이용수 1

Guven Ozkaya

소속기관 Bursa Uluda? University

주요연구분야 의약학 > 임상의학 > 정신과학

논문수 1 이용수 1

Canan Topcuo?lu