지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 58 - 65 (8page)
- DOI
- 10.31616/asj.2023.0115
이용수
초록· 키워드
오류제보하기
Study Design: Double-blind randomized controlled pilot study.
Purpose: The purpose of this study was to compare outcomes of steroids with autologous platelet-rich plasma (PRP) administered by lumbar transforaminal injection (LTI) in patients with lumbar radiculopathy.
Overview of Literature: Degenerative disc disease of the lumbar spine is one of the most common conditions managed by spine surgeons in routine practice. Once conservative management fails, LTI is diagnostic and often therapeutic. Steroids are the gold standard drug used for LTI but have limitations and side effects.
Methods: In this single-center double-blind randomized controlled pilot study, 46 patients were recruited and randomized by the lottery method. The Visual Analog Scale (VAS) for leg pain, modified Oswestry Disability Index (mODI), and Short-Form 12 (SF-12) were assessed at 1 week, 3 weeks, 6 weeks, 6 months, and 1 year.
Results: Both groups were comparable in terms of demographics, preprocedure VAS scores, mODI, and SF-12 scores (p=0.52). At the 1-week follow-up, the steroid group had significantly better improvement than the PRP group (p=0.0001). At the 3-week follow-up, both groups showed comparable outcomes; however, the PRP group had better symptom improvement. At 6 weeks and 6 months, the PRP group had better outcomes (VAS, p<0.0001; ODI, p=0.02; SF-12, p=0.002). Moreover, 17 and 16 patients in the steroid and PRP groups underwent repeat LTI with steroids or surgery because of pain recurrence during follow-up. At 1 year, no difference in outcomes was observed.
Conclusions: PRP may be a useful alternative to steroids for LTI in lumbar radiculopathy. Although improvement was delayed and 1-year outcomes were comparable, the 6-week and 6-month outcomes were better with PRP than with LTI. Multiple PRP injections may be beneficial because of its autologous nature. However, further studies with a larger number of participants, longer follow-up, and repeat LTIs are warranted to draw definite conclusions.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Can platelet-rich plasma injections provide better pain relief and functional outcomes in persons with common shoulder diseases: a meta-analysis of randomized controlled trials
대한견주관절의학회지
2022 .03
-
Prospective Clinical Research of the Efficacy of Platelet-rich Plasma in the Outpatient-based Treatment of Rotator Cuff Tendinopathy
대한견주관절의학회지
2019 .06
-
Platelet-rich plasma versus corticosteroid injections for rotator cuff tendinopathy: a comparative study with up to 18-month follow-up
대한견주관절의학회지
2022 .03
-
Does Platelet-rich Plasma Augmentation Following Hip Arthroscopy Improve Outcomes: A Systematic Review
Hip and Pelvis
2020 .01
-
Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction
Asian Spine Journal
2020 .01
-
Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study
Annals of Dermatology
2016 .01
-
Case Report for Platelet rich plasma (PRP) in 2 Dogs
WITH CAP(COMPANION ANIMAL PRACTICE)
2018 .04
-
Allogeneic Platelet-Rich Plasma Versus Corticosteroid Injection for the Treatment of Rotator Cuff Disease: A Randomized Controlled Trial
대한견주관절의학회 학술대회논문집
2021 .03
-
The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review
Journal of Yeungnam Medical Science
2022 .07
-
Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial
Asian Spine Journal
2017 .01
-
The benefit of platelet-rich plasma injection over institutionbased physical therapy program in adhesive capsulitis patients with diabetes mellitus: prospective observational cohort study
대한견주관절의학회지
2021 .12
-
Freeze-Dried Human Platelet-Rich Plasma Retains Activation and Growth Factor Expression after an Eight-Week Preservation Period
Asian Spine Journal
2017 .01
-
Platelet-Rich Plasma Injections as a Treatment for Refractory Patellar Tendinosis: A MetaAnalysis of Randomised Trials
Knee Surgery and Related Research
2017 .01
-
Platelet rich plasma versus corticosteroids for lateral epicondylitis: a meta-analysis of randomized clinical trials
대한견주관절의학회지
2025 .03
-
The Early Histological Effects of Intravesical Instillation of Platelet- Rich Plasma in Cystitis Models
International Neurourology Journal
2016 .01
-
Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats
Yonsei Medical Journal
2017 .01
-
Platelet-rich Plasma in Arthroscopic Rotator Cuff Repair
대한견주관절의학회지
2015 .06
-
Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial
Obstetrics & Gynecology Science
2022 .05
-
The Effect of Platelet Rich Plasma Dosage on the Tendon Healing in Rabbits
Archives of Hand and Microsurgery
2016 .01
-
Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs
Journal of Veterinary Science
2016 .03
최근 본 자료
댓글(0)
0