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논문 기본 정보

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학술저널
저자정보
Chiewchalermsri Chirawat (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.Department of Medicine Panyananthaphikkhu Chonprathan Medical Center Srinakharinwirot Unive) Sangkanjanavanich Sasipa (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.Division of Allergy Immunology and Rheumatology Department of Medicine Faculty of Medicine) Pradubpongsa Panitan (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.) Mitthamsiri Wat (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.) Jaisupa Nattapon (Department of Pharmacology Phramongkutklao College of Medicine Bangkok Thailand.) Jindarat Sarawut (Department of Pharmacology Phramongkutklao College of Medicine Bangkok Thailand.) Buranapraditkun Supranee (Center of Excellence in Vaccine Research and Development (Chula Vaccine Research Center Chula VRC) Faculty of Medicine Chulalongkorn University Bangkok Thailand.Department of Medicine Faculty of Medic) Jacquet Alain (Center of Excellence in Vaccine Research and Development (Chula Vaccine Research Center Chula VRC) Faculty of Medicine Chulalongkorn University Bangkok Thailand.) Sangasapaviliya Atik (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.) Boonpiyathad Tadech (Division of Allergy and Clinical Immunology Department of Medicine Phramongkutklao Hospital Bangkok Thailand.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.3
발행연도
2023.5
수록면
336 - 347 (12page)
DOI
10.4168/aair.2023.15.3.336

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Purpose: Vitamin D (VitD) is an immunomodulatory molecule capable of alleviating allergic symptoms. However, the effectiveness of allergen-specific immunotherapy (AIT) is not commonly evidenced in the early build-up phase. The aim of the study was to determine the potential of VitD supplementation in this treatment phase. Methods: Thirty-four house dust mite (HDM)-allergic adult patients treated with subcutaneous AIT were randomized to receive VitD2 60,000 IU/week or placebo for 10 weeks and followed up for 10 weeks. The primary endpoints were the symptom-medication score (SMS) and the treatment response rate. The secondary endpoints were eosinophil count and levels of plasma IL-10, Der p 2-specific IgG4, and dysfunctional regulatory T (CRTH2+ Treg) cells. Results: Of 34 patients, 15 in each group completed the study. Patients with VitD deficiency receiving a VitD supplement showed significantly lower mean change SMS than the placebo group in weeks 10 (mean difference −54.54%, P = 0.007) and 20 (mean difference −42.69%, P = 0.04). The percentage of treatment responders reached 78% and 50% in the VitD and placebo groups, respectively, and the effect remained in week 20 (89% and 60%). No significant difference was observed for the tested immunological read-outs, with the exception of the frequency of CRTH2+ Treg cells, which was remarkably reduced in the VitD-treated patients. Moreover, improvement in SMS was correlated to the number of CRTH2+ Treg cells. Our in vitro experiment indicated that VitD downregulated activation markers, whereas it improved the function of CRTH2+ Treg cells. Conclusions: VitD supplementation in the build-up phase of AIT could relieve symptoms and decrease Treg cell dysfunction, especially in patients with VitD deficiency.
#Vitamin D #alleric rhinitis #immunologic desensitization #antigens #Dermatophagoides #treatment outcome #regulatory T-lymphocytes

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