지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) are multipotent stem cells, which can be induced to differentiate into several cells. MSCs are also reported to possess immunomodulatory properties through secretion of inflammatory cytokines and generation of regulatory T (Treg) cells. Treg cells play an important role in allergic disorders, including atopic dermatitis. We examined the immunomodulatory effects of canine adipose tissue derived-MSCs (cAD-MSCs) in 3 groups: Group 1, untreated normal dog; Group 2, dogs with Dermatophagoides farinae ointment-induced atopic dermatitis; and Group 3, dogs with atopic dermatitis. Canine peripheral blood mononuclear cells (PBMCs) were collected from each group and co-cultured with cAD-MSCs. After co-culturing, PBMCs were separated and the expression of Treg cells was examined by flow cytometry. According to the results, the populations of Treg cells were increased in 3 ex vivo experimental groups, co-cultured with cAD-MSCs. These results would be important for the application of MSCs in clinical trials.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Aggarwal S / 2005 / Human mesenchymal stem cells modulate allogeneic immune cell responses / Blood 105:1815~1822
Anjos-Afonso F / 2004 / In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions / J Cell Sci 117:5655~5664
Batten P / 2006 / Human mesenchymal stem cells induce T cell anergy and downregulate T cell alloresponses via the TH2 pathway: relevance to tissue engineering human heart valves / Tissue Eng 12:2263~2273
Brandt C / 2009 / Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis / Allergy 64:1588~1596
Choi EW / 2015 / Therapeutic effects of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cell transplantation on established autoimmune thyroiditis / Cell Transplant 24:2221~2236
Anjos-Afonso F / 2004 / In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions / J Cell Sci 117:5655~5664
Batten P / 2006 / Human mesenchymal stem cells induce T cell anergy and downregulate T cell alloresponses via the TH2 pathway: relevance to tissue engineering human heart valves / Tissue Eng 12:2263~2273
Brandt C / 2009 / Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis / Allergy 64:1588~1596
Choi EW / 2015 / Therapeutic effects of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cell transplantation on established autoimmune thyroiditis / Cell Transplant 24:2221~2236
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