지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 278 - 290 (13page)
이용수
초록· 키워드
오류제보하기
The intestinal immune system maintains oral tolerance to harmless antigens or nutrients. One mechanism of oral tolerance is mediated by regulatory T cell (Treg)s, of which differentiation is regulated by a subset of dendritic cell (DC)s, primarily CD103<SUP>＋</SUP> DCs. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, plays an important role in regulating immunity. The intestines are exposed to various AhR ligands, including endogenous metabolites and phytochemicals. It was previously reported that AhR activation induced tolerogenic DCs in mice or in cultures of bone marrow-derived DCs. However, given the variety of tolerogenic DCs, which type of tolerogenic DCs is regulated by AhR remains unknown. In this study, we found that AhR ligand 3,3"-diindolylmethane (DIM) inhibited the development of CD103<SUP>＋</SUP> DCs from mouse bone marrow cells stimulated with Flt3L and GM-CSF. DIM interfered with phosphorylation of STAT3 and STAT5 inhibiting the expression of genes, including Id2, E2-2, IDO-1, and Aldh1a2, which are associated with DC differentiation and functions. Finally, DIM suppressed the ability of CD103<SUP>＋</SUP> DCs to induce Foxp3＋ Tregs.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (72)
참고문헌 신청
[학술지(정기간행물)] - Burbach, K. M. / 1992 / Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor / Proc. Natl. Acad. Sci. U.S.A 89 : 8185 ~ 8189
[학술지(정기간행물)] - Rushmore, T. H. / 1990 / Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants / J. Biol. Chem 265 : 14648 ~ 14653
[학술지(정기간행물)] - Swanson, H. I. / 1993 / The AH-receptor: genetics, structure function / Pharmacogenetics 3 : 213 ~ 230
[학술지(정기간행물)] - Huff, J. / 1994 / Carcinogenicity of TCDD: experimental, mechanistic, epidemiologic evidence / Annu. Rev. Pharmacol. Toxicol 34 : 343 ~ 372
[학술지(정기간행물)] - Nguyen, L. P. / 2008 / The search for endogenous activators of the aryl hydrocarbon receptor / Chem. Res. Toxicol 21 : 102 ~ 116
[학술지(정기간행물)] - Rushmore, T. H. / 1990 / Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants / J. Biol. Chem 265 : 14648 ~ 14653
[학술지(정기간행물)] - Swanson, H. I. / 1993 / The AH-receptor: genetics, structure function / Pharmacogenetics 3 : 213 ~ 230
[학술지(정기간행물)] - Huff, J. / 1994 / Carcinogenicity of TCDD: experimental, mechanistic, epidemiologic evidence / Annu. Rev. Pharmacol. Toxicol 34 : 343 ~ 372
[학술지(정기간행물)] - Nguyen, L. P. / 2008 / The search for endogenous activators of the aryl hydrocarbon receptor / Chem. Res. Toxicol 21 : 102 ~ 116
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UCI(KEPA) : I410-ECN-0101-2016-511-002258967