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학술저널
저자정보
Birmingham Janette M. (Divisions of Allergy and Clinical Immunology Icahn School of Medicine at Mount Sinai New York NY US) Chesnova Bogdana (Divisions of Allergy and Clinical Immunology Icahn School of Medicine at Mount Sinai New York NY US) Wisnivesky Juan P. (Divisions of General Internal Medicine Icahn School of Medicine at Mount Sinai New York NY USA.Divi) Calatroni Agustin (Rho Inc. Federal Systems Division Chapel Hill NC USA.) Federman Jessie (Divisions of Allergy and Clinical Immunology Icahn School of Medicine at Mount Sinai New York NY US) Bunyavanich Supinda (Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA) Busse Paula J. (Divisions of Allergy and Clinical Immunology Icahn School of Medicine at Mount Sinai New York NY US)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.4
발행연도
2021.1
수록면
646 - 654 (9page)

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T-regulatory cells (Tregs) play a key role in suppressing effector cells and maintaining self-tolerance. Studies of younger adults and children suggest that insufficient differentiation and functional defects of Tregs may contribute to the development of asthma; however, data from older patients with asthma are limited. To address the effects of aging on the relationship of Treg frequency and function with clinical outcomes, we collected induced sputum (differential cell count and Treg frequency) and peripheral blood (Treg function and frequency) from aged (> 60 years of age) and younger (20–40 years old) patients with asthma. In younger patients, low Treg suppression was associated with significantly higher mean numbers of emergency department (ED) (1.8 vs. 0.17, P = 0.02) and urgent care visits (2.3 vs. 0.17, P = 0.01) for asthma, and decreased asthma control (mean Asthma Control Test [ACT] score, 17 vs. 21.3, P = 0.01) compared to those with high Treg suppression. In older patients, however, a lower Treg function was not significantly associated with ACT scores (18.2 vs. 13.4, P = 0.10), or the number of ED (P = 0.9) or urgent care visits (P = 0.2). Our data suggest that Tregs have a weak relationship with asthma control and clinical asthma outcomes in older patients and differ from findings in younger patients, where Tregs are more likely to play a protective role.

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