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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 196 - 203 (8page)
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Purpose: Cutaneous lymphocyte-associated antigen (CLA)-expressing CD8+T cells have been known to play an important role in the pathogenesis of atopic dermatitis(AD). However, the mechanisms underlying the loss of self-tolerance remainunclear. Regulatory T cells (Tregs) play a key role in the development of homeostasisin the immune system. We, therefore, hypothesized that a reduced ability of Tregs to inhibit autologous CD8+CLA+T cells might be underlying mechanism in AD. Materials and Methods: CD8+CLA+T cells and Tregs were obtained from the peripheral blood of AD patients and control volunteers. The frequenciesof CD8+CLA+T cells were evaluated. The proliferative responses of CD8+CLA+T cells were assessed by flow cytometry, and the levels of transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) in culture supernatants were detected by enzyme-linked immunosorbent assay. Results: Our results revealed higher frequency and increased expression of perforin and granzyme-B in peripheralCD8+CLA+T cells in AD, and lower inhibitory ability of Tregs on proliferation of CD8+CLA+T cells in AD. Meanwhile, the levels of TGF-β1 produced by Tregs were significantly lower in AD, and anti-TGF-β1 abolished such suppression. Conclusion: The attenuated inhibitory ability of Tregs on hyper-activated autologousCD8+CLA+T cells, mediated by TGF-β1, plays an important role in the pathogenesis of AD.
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참고문헌 (22)
참고문헌 신청
Akdis M / 1997 / Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-
Akdis M / 1999 / Skin homing(cutaneous lymphocyte-associated antigen-positive)CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic
Bieber T / 2008 / Atopic dermatitis / N Engl J Med 358 : 1483 ~ 1494
Caproni M / 2007 / FoxP3-expressing T regulatory cells in atopic dermatitis lesions / Allergy Asthma Proc 28 : 525 ~ 528
Fontenot JD / 2003 / Foxp3 programs the development and function of CD4+CD25+ regulatory T cells / Nat Immunol 4 : 330 ~ 336
Akdis M / 1999 / Skin homing(cutaneous lymphocyte-associated antigen-positive)CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic
Bieber T / 2008 / Atopic dermatitis / N Engl J Med 358 : 1483 ~ 1494
Caproni M / 2007 / FoxP3-expressing T regulatory cells in atopic dermatitis lesions / Allergy Asthma Proc 28 : 525 ~ 528
Fontenot JD / 2003 / Foxp3 programs the development and function of CD4+CD25+ regulatory T cells / Nat Immunol 4 : 330 ~ 336
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