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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.7
- 수록면
- 557 - 565 (9page)
- DOI
- http://dx.doi.org/10.14348/molcells.2016.0079
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초록· 키워드
오류제보하기
The paired immunoglobulin-like type 2 receptor (PILR) family consists of two functionally opposite members, inhibitory PILR? and activating PILR? receptors. PILRs are widely expressed in various immune cells and inter-act with their ligands, especially CD99 expressed on activated T cells, to participate in immune responses. Here we investigated whether PILR-derived agonists inhibit ?1 integrin activity as ligands for CD99. PILR-derived peptides as well as PILR-Fc fusion proteins prevented cell adhesion to fibronectin through the regu-lation of ?1 integrin activity. Especially, PILRpep3, a representative 3-mer peptide covering the conserved motifs of the PILR extracellular domain, prevented the clustering and activation of ?1 integrin by dephosphory-lating FAK and vinculin, which are major components of focal adhesion. In addition, PILRpep3 inhibited transen-dothelial migration of monocytes as well as endothelial cell tube formation. Furthermore, upon intraperitoneal injection of PILRpep3 into mice with collagen-induced arthritis, the inflammatory response of rheumatoid arthritis was strongly suppressed. Taken together, these results suggest that PILR-derived agonist ligands may prevent the inflammatory reactions of rheumatoid arthri-tis by activating CD99.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Akhavani, M. A. / 2009 / Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis / Arthritis Res. Ther 3:64
Azcutia, V. / 2013 / CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions / Mol. Biol. Cell 21:3358~3368
Bauer, M. / 2009 / β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity / Proc. Natl. Acad. Sci. USA 6:1920~1925
Bernard, G. / 1995 / The E2 molecule(CD99)specifically triggers homotypic aggregation of CD4+ CD8+ thymocytes / J. Immunol 1:26~32
Bernard, G. / 1997 / Apoptosis of immature thymocytes mediated by E2/CD99 / J. Immunol 6:2543~2550
Azcutia, V. / 2013 / CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions / Mol. Biol. Cell 21:3358~3368
Bauer, M. / 2009 / β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity / Proc. Natl. Acad. Sci. USA 6:1920~1925
Bernard, G. / 1995 / The E2 molecule(CD99)specifically triggers homotypic aggregation of CD4+ CD8+ thymocytes / J. Immunol 1:26~32
Bernard, G. / 1997 / Apoptosis of immature thymocytes mediated by E2/CD99 / J. Immunol 6:2543~2550
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