지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제6호
- 발행연도
- 2017.6
- 수록면
- 1,189 - 1,197 (9page)
- DOI
- 10.4014/jmb.1701.01080
이용수
초록· 키워드
오류제보하기
Lichen-forming fungi are known to have various biological activities, such as antioxidant, antimicrobial, antitumor, antiviral, anti-inflammation, and anti proliferative effects. However, the immunosuppressive effects of Bryoria sp. extract (BSE) have not previously been investigated. In this study, the inhibitory activity of BSE on the proliferation of CD8+ T cells and the mixed lymphocytes reaction (MLR) was evaluated in vitro. BSE was non-toxic in spleen cells and suppressed the growth of splenocytes induced by anti-CD3. The suppressed cell population in spleen cells consisted of CD8+ T cells and their proliferation was inhibited by the treatment with BSE. This extract significantly suppressed the IL-2 associated with T cell growth and IFN-γ as the CD8+ T cell marker. Furthermore, BSE reduced the expression of the IL-2 receptor alpha chain (IL-2Rα) on CD8+ T cells and CD86 on dendritic cells by acting as antigen-presenting cells. Finally, the MLR produced by the co-culture of C57BL/6 and MMCtreated BALB/c was suppressed by BSE. IL-2, IFN-γ, and CD69 on CD8+ T cells in MLR condition were inhibited by BSE. These results indicate that BSE inhibits the MLR via the suppression of IL-2Rα expression in CD8+ T cells. BSE has the potential to be developed as an anti-immunosuppression agent for organ transplants.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Kobayashi K / 2001 / Immunopathogenesis of delayed-type hypersensitivity / Microsc. Res. Tech 53:241~245
Yin Y / 2008 / Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita / J. Ethnopharmacol 120:1~6
Taylor AL / 2005 / Immunosuppressive agents in solid organ transplantation: mechanisms of action and therapeutic efficacy / Crit. Rev. Oncol. Hematol 56:23~46
Bueno V / 2002 / The role of CD8+ T cells during allograft rejection / Braz. J. Med. Biol. Res 35:1247~1258
Castello M / 2005 / Evaluation of lichen diversity as an indicator of environmental quality in the North Adriatic submediterranean region / Sci. Total Environ 336:201~214
Yin Y / 2008 / Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita / J. Ethnopharmacol 120:1~6
Taylor AL / 2005 / Immunosuppressive agents in solid organ transplantation: mechanisms of action and therapeutic efficacy / Crit. Rev. Oncol. Hematol 56:23~46
Bueno V / 2002 / The role of CD8+ T cells during allograft rejection / Braz. J. Med. Biol. Res 35:1247~1258
Castello M / 2005 / Evaluation of lichen diversity as an indicator of environmental quality in the North Adriatic submediterranean region / Sci. Total Environ 336:201~214
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System
Molecules and Cells
2021 .01
-
Beyond the Molecular Facilitator, CD82: Roles in Metastasis Suppressor, Stem Cell Niche, Muscle Regeneration, and Angiogenesis
생명과학회지
2021 .09
-
Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200
극지연구소 초록집
2024 .07
-
CD133 Regulates IL-1β Signaling and Neutrophil Recruitment in Glioblastoma
Molecules and Cells
2017 .07
-
The Role of Lymphatic Niches in T Cell Differentiation
Molecules and Cells
2016 .07
-
Anti-melanogenic effects of Hordeum vulgare L. barely sprout extract in murine B16F10 melanoma cells
Journal of Nutrition and Health
2019 .04
-
Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells
Genes & Genomics
2024 .03
-
Segmented Filamentous Bacteria Induce Divergent Populations of Antigen-Specific CD4 T Cells in the Small Intestine
Molecules and Cells
2019 .01
-
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Molecules and Cells
2019 .01
-
Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine β-Lactoglobulin in Mice
Journal of Microbiology and Biotechnology
2015 .01
-
Quantitative analysis of aflatoxin B1-caused CD133 and CD44 positive cancer stem cells using AOTF based multi-color imaging system
한국분석과학회 학술대회
2017 .05
-
결핵 발병과 CD44 유전자 다형성사이의 연관성 연구
대한임상검사과학회지
2019 .01
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
-
The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Genes & Genomics
2021 .01
-
Association between CD53 genetic polymorphisms and tuberculosis cases
Genes & Genomics
2019 .01
-
CD1b in immature dendritic cells acquires increased phagocytotic function
미생물학회지
2018 .09
-
Biosorption of Cd by an indigenous Cd-resistant bacterium isolated from soil contaminated with Cd
Geosciences Journal
2024 .02
-
Fabrication of CdS/CdTe thin film solar cells by r.f. magnetron sputtering technique
한국진공학회 학술발표회초록집
2015 .02
-
Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow
Molecules and Cells
2021 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0