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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 668 - 677 (10page)
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초록· 키워드
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Embryo implantation is the crucial step for a successful pregnancy. Diverse factors, including adhesion molecules, growth factors, and cytokines are important for embryo implantation through improving endometrial receptivity. Benzoic acid (BA), a component of various plants, has been shown to have antifungal and antioxidant effects. However, the effect of BA on embryo implantation remains unknown. Here, we showed the contribution of BA for the enhancement of endometrial receptivity through the leukemia inhibitory factor (LIF)- dependent increase of integrin αV, β3, and β5 expression. Furthermore, in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos. Taken together, we suggest that BA has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.
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참고문헌 (23)
참고문헌 신청
Aghajanova L. / 2010 / Update on the role of leukemia inhibitory factor in assisted reproduction / Curr. Opin. Obstet. Gynecol 22 : 213 ~ 219
Aschenbach LC / 2013 / The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys / Contraception 87
Cervantes A / 1988 / The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells / Cancer Let
Cheung K / 1984 / Luminoldependent chemiluminescence produced by neutrophils stimulated by immune complexes / Aust. J. Exp. Biol. Med. Sci 62 : 403 ~ 419
Cullinan EB / 1996 / Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo
Aschenbach LC / 2013 / The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys / Contraception 87
Cervantes A / 1988 / The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells / Cancer Let
Cheung K / 1984 / Luminoldependent chemiluminescence produced by neutrophils stimulated by immune complexes / Aust. J. Exp. Biol. Med. Sci 62 : 403 ~ 419
Cullinan EB / 1996 / Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo
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